Method and device for detecting circulating abnormal cells

A technology for abnormal cells and cell nuclei, applied in the field of detecting circulating abnormal cells, can solve the problems of low subjectivity reliability, high detection cost, low detection efficiency, etc., achieve high detection reliability and precision, and avoid the influence of subjectivity , the effect of improving reliability and accuracy

Active Publication Date: 2020-10-02
ZHUHAI LIVZON CYNVENIO DIAGNOSTICS +1
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Problems solved by technology

However, the method for detecting CACs is based on the morphological information of CACs and combined with manual intervention to detect, confirm and count CACs. The detection is highly subjective and the reliability is not high, and due to the need for manual participation, the detection efficiency is low. High detection cost

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  • Method and device for detecting circulating abnormal cells
  • Method and device for detecting circulating abnormal cells
  • Method and device for detecting circulating abnormal cells

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Embodiment Construction

[0057] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is a part of embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making...

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Abstract

The invention provides a method and device for detecting circulating abnormal cells, and the method for detecting circulating abnormal cells comprises the steps: respectively segmenting and marking cell nucleuses contained in dark-field microscope images of a plurality of probe channels through an image processing algorithm and a morphological algorithm; inputting the dark-field microscope imagesof the plurality of probe channels for marking the cell nucleus into a pre-constructed circulating abnormal cell detection model to obtain the number of staining signals contained in each marked cellnucleus in the dark-field microscope image of each probe channel; and for each marked cell nucleus, determining whether the marked cell nucleus belongs to circulating abnormal cells or not based on the number of staining signals contained in the marked cell nucleus in the obtained dark-field microscope image of each probe channel. The reliability of detecting the circulating abnormal cells can beeffectively improved.

Description

technical field [0001] The invention relates to the technical field of cell detection, in particular to a method and device for detecting circulating abnormal cells (CACs, Circulating Abnormal Cells). Background technique [0002] Circulating tumor cells (CTCs, Circulating Tumor Cells) are cells that shed from the primary tumor and form secondary tumors in distant organ sites during tumor metastasis. A large number of studies have shown that the number of CTCs in the blood can predict the progression of the disease and indicate the tumor's response to chemotherapy drugs. Therefore, by collecting a certain amount of peripheral blood, CTCs can be detected from the peripheral blood and the changes in the content of CTCs in the blood can be monitored. , can be used to analyze the pathogenesis of tumors, evaluate the prognosis of patients, and understand the improvement of clinical conditions and drug resistance of patients after receiving treatment. [0003] In recent years, ci...

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Application Information

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IPC IPC(8): G06T7/00G06K9/00G06K9/62G06N3/04
CPCG06T7/0012G06T2207/10061G06V20/695G06V20/698G06N3/045G06F18/253G06T2207/10056G06T2207/20081G06T2207/20084G06T2207/30024C12Q1/68C12Q2563/173C12Q2565/601G06T7/11G06V20/70G06V2201/03G06V10/774G06T5/20G06T2207/20036G06T2207/30096G06T5/70
Inventor 范献军蓝兴杰叶莘张义李丛胜
Owner ZHUHAI LIVZON CYNVENIO DIAGNOSTICS
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