Pharmaceutical composition for improving cognitive impairment as well as preparation method and application thereof
A technology to improve cognition and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the limitation of anti-AD drug active ingredient definition and derivative drug development, and there are few studies on non-volatile oily ingredients , Difficult to obtain satisfactory therapeutic effects of drugs, etc., to achieve the effects of improving therapeutic effects, improving cognitive impairment, and simple preparation methods
Inactive Publication Date: 2020-10-09
GUANGDONG PHARMA UNIV
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Problems solved by technology
However, previous studies at home and abroad generally believed that the main active ingredient of Shichangpu was volatile oil, and there were few studies on non-volatile oily ingredients.
Moreover, the extraction method for the effective part of Shichangpu is relatively single and untargeted, and it is generally difficult to obtain a satisfactory therapeutic effect for a drug with a single action point.
Method used
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Embodiment 1
[0019] One, the preparation of medicine:
[0020] The medicinal material of Shichangpu has been identified as the dried rhizome of authentic Araceae plant Shichangpu. The medicinal material is coarsely powdered and passed through a No. 2 sieve (20 mesh). Extract the volatile oil part, the water extract part and the deoiled water decoction part of the coarse powder of medicinal materials respectively. The specific extraction methods are: (1) The part of the volatile oil: Weigh 200g of the coarse powder of Acorus calamus, add 10 times the amount of 60°C warm salt water containing 10g / L of sodium chloride and soak for 2 hours, add a few grains of zeolite, and use steam distillation to extract , When the volatile oil no longer increases, stop heating. Collect the volatile oil, dilute it with 1% Tween-80 100 times and store it for later use; (2) Part of the water extract: 200g of Acorus calamus coarse powder, add 15 times the amount of 60 ℃ warm water to soak for 2 hours, reflux e...
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The invention discloses a pharmaceutical composition for improving cognitive impairment as well as a preparation method and an application of the pharmaceutical composition. The pharmaceutical composition for improving cognitive impairment is prepared from rhizoma acori graminei volatile oil, rhizoma acori graminei water extract and D-serine. The pharmaceutical composition is obtained by extracting two effective parts, namely volatile oil and water extract, from rhizoma acori graminei and then mixing the two effective parts with D-serine, and obtaining the pharmaceutical composition capable ofremarkably improving cognitive disorder and used for preparing a medicine for improving cognitive disorder. The pharmaceutical composition disclosed by the invention is simple in preparation method and low in cost, has an obvious treatment effect of improving cognition, and has a wide market prospect.
Description
Technical field: [0001] The invention belongs to the field of biotechnology, and in particular relates to a pharmaceutical composition for improving cognitive impairment, a preparation method and application thereof. Background technique: [0002] With the improvement of medical level and quality of life, the average life expectancy of human beings is generally extended, and the world population has begun to age. At present, dementia has ranked first among neurological diseases in western countries, and two-thirds of them have been diagnosed as Alzheimer's disease (AD). AD is a common primary irreversible neurodegenerative disease with cognitive impairment and memory loss. It is the fourth leading cause of death after tumors, cardiovascular diseases and strokes, and its clinical features are mainly cognitive and behavioral disorders such as spatial learning and memory. Alzheimer's Disease International (ADI) announced that there were more than 50 million AD patients worldw...
Claims
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Login to View More IPC IPC(8): A61K36/888A61P25/28A61K31/198
CPCA61K31/198A61K36/888A61K2236/331A61K2236/39A61K2236/51A61P25/28A61K2300/00
Inventor 马宇昕周畅田素民李国营刘靖
Owner GUANGDONG PHARMA UNIV