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Composition comprising stem cell-derived exosomes for adipogenic differentiation induction, adipose tissue regeneration, skin whitening or wrinkle amelioration

A fat source, skin whitening technology, applied in the direction of epidermal cells/skin cells, bone/connective tissue cells, skin care preparations, etc., can solve the problem of difficulty in completely purifying exosomes

Pending Publication Date: 2020-10-16
EXOSTEMTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, in the currently used stem cell-derived exosome isolation method, it is difficult to completely purify exosomes due to the intervention of proteins in the medium or serum in the step of isolating the secretome including exosomes.

Method used

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  • Composition comprising stem cell-derived exosomes for adipogenic differentiation induction, adipose tissue regeneration, skin whitening or wrinkle amelioration
  • Composition comprising stem cell-derived exosomes for adipogenic differentiation induction, adipose tissue regeneration, skin whitening or wrinkle amelioration
  • Composition comprising stem cell-derived exosomes for adipogenic differentiation induction, adipose tissue regeneration, skin whitening or wrinkle amelioration

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Embodiment approach

[0026] According to one embodiment of the present invention, the composition may include, as an active ingredient, exosomes derived from stem cells differentiated into adipocytes. The composition can differentiate stem cells into adipocytes. Therefore, the composition can be used as a composition for inducing differentiation into adipocytes.

[0027] As used herein, the term "regenerate adipose tissue" refers to by restoring damaged adipose tissue or inducing the production of defective adipose tissue.

[0028] Additionally, the composition can regenerate adipose tissue. Therefore, the composition can be used as a composition for regenerating adipose tissue.

[0029] According to another embodiment of the present invention, the composition for inducing differentiation into adipocytes or regenerating adipocyte tissue can be used as a pharmaceutical composition. In particular, the content of the pharmaceutical composition may be 0.001 to 10 parts by weight based on 100 parts ...

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Abstract

The present invention relates to a pharmaceutical composition for adipocyte differentiation induction and / or adipose tissue regeneration comprising, as an active ingredient, an exosome extracted froma stem cell which is differentiating into an adipocyte. The exosome is excellent in expression rate of bioactive factors influencing the differentiation into an adipocyte and has the effect of differentiating a stem cell into an adipocyte. Accordingly, the present invention can be applied to differentiation inducing agents of a stem cell, injections for tissue regeneration, fillers for cosmetic purposes, preparations for tissue engineering, etc. The invention also relates to a cosmetic composition for skin whitening, wrinkle improvement and regeneration, containing an exosome extracted from astem cell as an active ingredient. Since the exosome contains genes, proteins, growth factors etc. associated with the proliferation, differentiation, and regeneration of stem cells; is a purified component that does not include antibiotics, serums or culture solution harmful factors; and is a cell-derived lipid transporter, the exosome can be applied to functional cosmetic compositions having skin whitening, wrinkle improvement and skin regeneration functions and scar improving preparations for cosmetic purposes, etc.

Description

technical field [0001] The present invention relates to a composition for inducing stem cells to differentiate into adipocytes and / or regenerating adipose tissue using stem cell-derived exosomes containing adipocyte differentiation-inducing substances. In addition, the present invention relates to a cosmetic composition comprising stem cell-derived exosomes for skin whitening, wrinkle improvement or skin regeneration. Background technique [0002] As a therapeutic method for regenerating adipose tissue, there is a method using a therapeutic agent including stem cells cultured using a matrix having adipose tissue three-dimensionally cultured in a hydrogel. Growth factors and extracellular matrix can be secreted by stem cells after three-dimensional culture of the tissue in a hydrogel. However, in order for the therapeutic agent to be used as an injectable dosage form, it is inconvenient to remove the hydrogel in thin film form from the culture vessel and to treat the tissue ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/64A61K8/14A61Q19/02A61Q19/08A61K35/12A61K9/127A61K47/24A61K35/545A61P17/00A61P17/02
CPCA61K8/02A61K8/98A61K8/99A61K9/0019A61K9/06A61K35/28A61K35/51A61Q19/00A61Q19/02A61Q19/08A61P17/02A61P17/18A61P17/00A61K2800/86C12N5/0629C12N5/0656C12N5/0667C12N2502/1382A61K8/981A61K2800/70C12N5/0653A61K2800/74A61K2800/805A61K35/12A61K8/31A61K8/342A61K8/345A61K8/361A61K8/41A61K8/585A61K8/8105A61K8/86A61K8/925A61K35/35C12N2500/90C12N2501/135C12N2501/15C12N2501/22C12N2501/231C12N2501/25C12N2501/33C12N2501/355C12N2501/48C12N2501/50C12N2501/734C12N2506/1384A61K8/0216
Inventor 赵容佑崔志淑梁成贤李炅洙金垠志尹和仁金俊成
Owner EXOSTEMTECH CO LTD
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