Spontaneous mutation hairless SHJHhr/hr premature aging mouse animal model and breeding method thereof

A technology of animal model and breeding method, applied in the animal model of spontaneously mutated hairless SHJHhr/hr early-aging mice and its breeding field, can solve the problems affecting experimental results, animal influence, modeling limitations, etc., and improve the scope of application Effect

Active Publication Date: 2020-10-30
上海吉辉实验动物饲养有限公司
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  • Abstract
  • Description
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Problems solved by technology

[0004] The purpose of the present invention is to provide a spontaneous mutant hairless SHJH hr/hr Premature aging mouse animal model and breeding method, and independently developed and

Method used

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Embodiment Construction

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] The invention provides a technical solution: a spontaneous mutant hairless SHJH hr / hr A mouse animal model of premature aging and a breeding method thereof, comprising the steps of:

[0023] Step 1: Breed the occasional depilated mice and their brothers and sisters in the group until they are over 8 weeks old. The male and female depilated mice are mated with the normal hairy mice in the same litter respectively. The offspring are reared for 2 weeks and counted for each litter The proportion of hair-shedding mice.

[0024] ...

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Abstract

The present invention discloses a spontaneous mutation hairless SHJHhr/hr premature aging mouse animal model and a breeding method thereof. Mice in the mutation model are sensitive to some toxic substances and carcinogens, and can be widely used in cosmetics, skin ointments, photoallergy, photoaging, anti-skin cancer drugs, etc. At the same time, processes of skin aging through keratinization andwrinkling of the mice are similar to those of human, the mice can be used for research of skin stem cells, skin allergy tests, skin infection tests, screening of anti-skin cancer drugs, etc., and canalso be bred in large scale and better serve biological researches.

Description

technical field [0001] The invention belongs to the technical field of development and preservation of experimental animal resources, and in particular relates to a spontaneous mutant hairless SHJH hr / hr Mouse animal model of premature aging and its breeding method. Background technique [0002] Many studies have been carried out on hairless mutant mice at home and abroad. The earliest report was a case of hairless mice accidentally discovered by Brooke in the mouse population. Later, Gaskoin reported the hairless rhinoceros-hide mice, whose hairless features were more severe than those of general hairless mice, and the skin with With the growth of age, it gradually produces serious wrinkles, which look like "rhinoceros hide". Crossover experiments show that this hrrh is the allele of hr [3]. The hairless gene (hr) is located on chromosome 14 and is an autosomal recessive inheritance. In 1989, Cachón-González and others cloned the hairless gene (hr), which was speculated...

Claims

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 谈小倩
Owner 上海吉辉实验动物饲养有限公司
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