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Application of borneol in preparation of brain glioma radiotherapy combined medicine

A technology for glioma and malignant glioma, which is applied in the application field of borneol in the preparation of glioma radiotherapy combined medicine, and achieves the effect of strong scientific significance

Inactive Publication Date: 2020-11-03
ZHEJIANG CANCER HOSPITAL
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Problems solved by technology

However, the clinical effect of Chinese medicine borneol combined with radiotherapy in the treatment of glioma, as well as the regulation and molecular mechanism of HIF-1α have not been reported yet.

Method used

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  • Application of borneol in preparation of brain glioma radiotherapy combined medicine
  • Application of borneol in preparation of brain glioma radiotherapy combined medicine
  • Application of borneol in preparation of brain glioma radiotherapy combined medicine

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[0043] main content:

[0044] (1) Construct a rat intracranial glioma model, observe the inhibitory effect of borneol combined with radiotherapy and radiotherapy on glioma, compare the volume and weight of glioma in each group, and calculate the relative tumor volume (RTV) and relative tumor volume. Proliferation rate (T / C) and tumor inhibition percentage. The expression levels of HIF-1α and mTORC1 / eIF4E proteins in rat brain glioma tissues were further detected by immunohistochemical method.

[0045] (2) Construct an in vitro model of primary cultured glioma cells, simulate a hypoxic environment, conduct cell proliferation detection, and study the effect of borneol combined with radiotherapy on the activity of glioma cells and the regulation of the expression of mTORC1, eIF4E, and HIF-1α effect. The mTORC1 and / or eIF4E gene was silenced by siRNA / plasmid transfection, and the expression levels of HIF-1α gene and protein were determined by Western Blot and immunofluorescence ...

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Abstract

The invention relates to the field of tumor drugs, and discloses an application of borneol in preparation of a brain glioma radiotherapy combined drug. The inventor of the invention finds that borneolcan effectively enhance the sensitivity of malignant brain glioma radiotherapy, and the effect may be that the expression of HIF1a is regulated and controlled by mediating mTORC1 / eIF4E signaling pathways so as to reverse radiotherapy resistance, so that borneol can be used as a malignant brain glioma radiotherapy combined drug.

Description

technical field [0001] The invention relates to the field of tumor drugs, in particular to the application of borneol in the preparation of glioma radiotherapy combination medicine. Background technique [0002] Glioma is the most common intracranial malignant tumor, which not only compresses normal brain tissue, causes increased intracranial pressure, leads to nervous system dysfunction, but also seriously threatens the health and life safety of patients. Among them, high-grade glioma (WHO grade III, IV glioma) has a high incidence, accounting for about 35% to 45% of primary intracranial malignant tumors. The current clinical treatment of malignant glioma is surgery-based, but it still has the characteristics of high recurrence rate and low survival rate. Postoperative radiotherapy is one of the main methods in the treatment of glioma. About 70% of patients need radiotherapy, but the curative effect is not good. The median survival time is only 14 weeks, and the median su...

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Application Information

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IPC IPC(8): A61K31/045A61P35/00
CPCA61K9/0019A61K31/045A61P35/00
Inventor 王增程向东杨国浓李清林夏亮蔡鑫君
Owner ZHEJIANG CANCER HOSPITAL
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