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Application of aerosol allicin in prevention and treatment of new coronavirus infection and other respiratory tract infectious diseases

A technology for allicin and virus infection, which is applied in the field of medicine and achieves the effects of good effect, improved patient compliance, low price and large quantity

Inactive Publication Date: 2020-11-13
JINSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also do not see any method of applying allicin to the human body in the existing research results

Method used

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  • Application of aerosol allicin in prevention and treatment of new coronavirus infection and other respiratory tract infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 mashed garlic aerosol inhalation method

[0032] Take 1 to 2 cloves of fresh garlic, use a garlic press or a garlic pounder to make garlic paste, put the garlic paste in a spoon, put the spoon in your mouth, breathe in through your mouth and out through your nostrils, and take a deep breath for 10-15 minutes minute;

[0033] Note: Every time you inhale through your mouth, you need to inhale full air and swallow to ensure that the allicin is inhaled deep into the respiratory tract and reach the lungs; residence time within. After 10-15 minutes, take the spoon out of your mouth and discard the mashed garlic. During the above process, a large amount of nasal mucus, phlegm and other excrement may be produced, and even a handful of nasal mucus and tears may appear. In this case, you should keep breathing, and expel the mucus, phlegm, tears, etc. in time and fully.

[0034] Every morning and evening can do a prevention. Or take a precaution immediately after...

Embodiment 2

[0035] Embodiment 2 garlic powder aerosol inhalation method

[0036] Take one capsule (100mg / capsule) at a time of qualified garlic dry powder capsule preparation produced by the manufacturer and place it in the powder inhalation device (apparatus and powder are available in the market), press the button to puncture the capsule; suck the powder into the mouth with your mouth, and do a swallowing action , to ensure that allicin is inhaled into the deep part of the respiratory tract; repeat the operation 2 to 4 times, and use one capsule for inhalation every morning and evening for prevention. Do not increase the dose or frequency during treatment.

Embodiment 3

[0037] Embodiment 3 clinical trial (1)

[0038] 1 clinical data

[0039] The fever clinic of Jinshan Hospital Affiliated to Fudan University randomly selected 200 volunteers, including 16 medical staff of the fever clinic, 70 fever patients, 70 family members of patients, 40 suspicious contacts, and 4 people who tested positive for nucleic acid.

[0040] 2 test method

[0041] From April 1, 2020 to July 31, during the outbreak of novel coronavirus pneumonia, 100 of the above-mentioned patients used the garlic aerosol inhalation method of the present invention for a period of 14 days of self-protection treatment, daily garlic spicy Suction inhalation operation 2 times, once in the morning and evening. Garlic is purchased by everyone in the local supermarket. 100 people took the garlic-based dry powder inhalation method produced by Wuxi Hongrui Biomedical Technology Co., Ltd. The specific operation method can refer to any one of the methods described in Examples 1-2.

[004...

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Abstract

The invention relates to application of aerosol allicin to prevention and treatment of new coronavirus infection and other respiratory tract infectious diseases. The research finds that the new coronavirus only invades and infects respiratory tract epithelial cells expressing ACE2 and TMPRSS2; aerosol allicin can effectively inhibit TMPRSS2, so that new coronavirus is prevented from entering and infecting cells, infection factors in alveolar air can be eliminated, and new coronavirus infection can be effectively prevented and treated. In addition, the invention also finds that the aerosol allicin can effectively prevent and treat respiratory system diseases caused by infection factors of bacteria (such as mycobacterium tuberculosis, and Yersinia pestis), fungi (such as candida albicans andaspergillus niger), parasites (such as amoeba, giardia and leishmania), rickettsia and mycoplasma, and other viruses (such as influenza A, influenza B, encephalitis B, SARS, MERS, avian influenza and African swine fever) of non-SARSARS-CoV-2. Clinical application prospect is wide.

Description

technical field [0001] The present invention relates to the technical field of medicine, specifically, the application of aerosol allicin in the prevention and treatment of new coronavirus infection and other respiratory infectious diseases. Background technique [0002] SARS-CoV-2, like other viruses, is a non-cellular life form, without its own metabolic mechanism, without an enzyme system, and without the host cell, it becomes a chemical substance without any life activities and cannot reproduce independently. Virus infection from entering the host cell. Hoffman et al. (1) The process by which SARS-CoV-2 enters host cells is elucidated. They found that SARS-CoV-2, similar to other coronaviruses, uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter cells through the spike (S) protein on the viral envelope. Furthermore, the host serine protease (TMPRSS2) is essential for the processing of the viral S protein as a prerequisite for the S protein-ACE2 interact...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/105A61P31/14A61P11/00A61P31/00
CPCA61K9/12A61K9/0073A61K31/105A61P31/14A61P11/00A61P31/00
Inventor 齐绪林汤鲁宏
Owner JINSHAN HOSPITAL FUDAN UNIV
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