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A controllable degradable embolic microsphere responsive to magnetic response hyperthermia and its preparation method and application

A technology of embolization microspheres and magnetic response, which is applied in the field of biological and medical nanomaterials, can solve the problems of large individual differences and uncontrollable degradation cycle of degradable embolization microspheres, so as to reduce damage, increase saturation magnetization and resist Oxidation ability, the effect of accelerating the degradation of microspheres

Active Publication Date: 2022-06-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation cycle of existing degradable embolization microspheres in vivo is uncontrollable. For example, the degradation cycle of PLA embolization microspheres in vivo is as long as one year, while the degradation cycle of gelatin embolization microspheres in vivo is as short as several weeks. Therefore, in order to improve the quality of the patient's recovery, there is an urgent need for an embolic microsphere that can selectively control the degradation according to the patient's embolization treatment process.

Method used

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  • A controllable degradable embolic microsphere responsive to magnetic response hyperthermia and its preparation method and application
  • A controllable degradable embolic microsphere responsive to magnetic response hyperthermia and its preparation method and application
  • A controllable degradable embolic microsphere responsive to magnetic response hyperthermia and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Determination of hysteresis loop of magnetic iron oxide with particle size of 10, 50, 100, 200, 300, 400, 500, 600 nm

[0033] Weigh 8 mg of magnetic iron oxide particles of the above specifications respectively, and measure the hysteresis loop of the sample with a vibrating sample magnetometer (VSM). The results are shown in Table 1:

[0034] Table 1

[0035]

[0036]

[0037] According to Table 1, it can be seen that the saturation magnetization of magnetic iron oxide is related to the particle size. The larger the particle size, the stronger the saturation magnetization. The particle size is in the range of 200-500nm, and the saturation magnetization of magnetic iron oxide is greater than 80emu / g. Among them, the hysteresis loops of magnetic iron oxide with particle size of 10nm and 300nm are as follows figure 1 As shown in the figure, the saturation magnetization of the magnetic iron oxide with a particle size of 10 nm is 57 emu / g, and the saturation magnetiz...

Embodiment 2

[0039] Preparation of 10nm-scale magnetic iron oxide carrageenan-gelatin plugging microspheres by emulsification and cross-linking method

[0040] Weigh 0.6 g of gelatin, 0.6 g of carrageenan and 50 mg of 10-nm-grade magnetic iron oxide powder, slowly sprinkle the powder in 10 mL of pure water, and swell at 55° C. for 20 min to prepare an aqueous phase. Measure 50 mL of liquid paraffin, add 0.4 g of Span80 dropwise, and preheat at 55°C to prepare an oil phase. The oil phase was slowly poured into the water phase, and stirred at 55° C. and 800 rpm for 30 min to form colostrum. Stir and cool for 30 min, drop 1.5 mL of 25% glutaraldehyde solution, and continue to stir and crosslink for 1 h. Finally, 30 mL of isopropanol was added to stir and dehydrate for 15 minutes, then washed with isopropanol, water and anhydrous ethanol in stages, filtered with suction, dried in an oven at 60°C for 30 minutes, ground and sorted to obtain microspheres. The dried microspheres are brownish yel...

Embodiment 3

[0042] Preparation of 50nm-sized Magnetic Iron Oxide Carrageenan-Gelatin Embolization Microspheres by Emulsification and Cross-linking

[0043]Weigh 0.6g of gelatin, 0.6g of carrageenan and 50mg of 50nm magnetic iron oxide powder, slowly sprinkle the powder in 10mL of pure water, and swell at 55°C for 20min to make the water phase. Measure 50mL of liquid paraffin, add 0.4g of Span80 dropwise, and preheat at 55°C to make an oil phase. Slowly inject the oil phase into the water phase, stir at 55°C and 800rpm for 30min to form colostrum. Stir and cool for 30 min, add 1.5 mL of 25% glutaraldehyde solution dropwise, and continue stirring for 1 h to cross-link. Finally, 30 mL of isopropanol was added, stirred and dehydrated for 15 minutes, then washed with isopropanol, water and absolute ethanol several times, filtered with suction, dried in an oven at 60°C for 30 minutes, ground and sorted to obtain microspheres. Dried microspheres are brownish-yellow with uniform particle size. ...

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Abstract

The invention discloses a magnetically responsive hyperthermia controllable degradable embolic microsphere. In the magnetically responsive thermotherapy controllable degradable embolic microsphere, degradable materials such as carrageenan and gelatin are used as mixed glue, and the particle size is 200-500nm oxidized. Iron as a high-efficiency magnetothermal developer. This is a new type of microsphere that integrates embolization, nuclear magnetic imaging, magnetothermal, and controllable degradation, and can be used to treat tumors and other diseases. The invention also discloses the preparation method of the microspheres. By means of water-in-oil or oil-in-water, the saturation magnetization is better, the anti-oxidation ability in the preparation process is the strongest, and the particle size range of 200 is excellent in magnetocaloric heating performance. ‑500nm magnetic iron oxide is loaded into the embolization microspheres, which realizes the synchronization of imaging and embolization, improves the accuracy of embolization operation, and under the action of a magnetic field, the temperature is raised to 40‑45°C through the magnetocaloric effect, which can play a role in hyperthermia synergistic killing The role of tumor lesions can improve the treatment effect. When the treatment reaches expectations, the temperature of the microspheres can be raised to 49-55°C through the magnetocaloric effect, which can accelerate the degradation of embolism microspheres, achieve embolism and then unblock, and reduce damage to normal tissues.

Description

technical field [0001] The invention belongs to the technology of biological and medical nanomaterials, in particular to a magnetically responsive hyperthermia controllable degradable embolization microsphere and a preparation method and application thereof. Background technique [0002] In January 2019, the National Cancer Center released the latest issue of the National Cancer Statistics Report. The report pointed out that in 2015, there were about 3.929 million malignant tumor incidences and 2.338 million deaths in China. That is to say, more than 10,000 people are diagnosed with cancer every day and 7.5 people are diagnosed every minute. In the past 10 years, the incidence of malignant tumors in my country has maintained an annual increase of about 3.9%, and the mortality rate has maintained an annual increase of 2.5%. Chinese people spend hundreds of billions of dollars on cancer treatment every year. [0003] There are many ways to treat tumors, and there are corresp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/02A61L24/00A61K49/18A61K49/14A61K41/00A61P35/00
CPCA61L24/104A61L24/08A61L24/02A61L24/0015A61L24/0042A61L24/001A61K49/14A61K49/1863A61K49/1866A61K41/0052A61P35/00A61L2430/36A61L2300/416A61L2300/102C08L5/00
Inventor 熊非黄锦鑫
Owner SOUTHEAST UNIV
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