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Application of garlic and allium mongolicum regel composition in preparation of antiviral product

A composition and antiviral technology, applied in the field of medicine, can solve problems such as limiting therapeutic effects, achieve high safety, and inhibit replication and reproduction

Inactive Publication Date: 2020-11-20
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no specific drug specifically for human infection with Influenza A (H1N1), and two types of anti-influenza drugs are commonly used: 1) adamantanes (adamantanes and remantadine), and 2) neuraminidase inhibitors of influenza (da However, human cases of influenza A H1N1 virus infection obtained from the United States showed that the mutant virus was resistant to two of them, and resistant to Tamiflu and Zanamivir. Alkylamines are sensitive, but resistant to amantadine and remantadine, and influenza viruses develop resistance to antiviral drugs, limiting therapeutic efficacy

Method used

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  • Application of garlic and allium mongolicum regel composition in preparation of antiviral product
  • Application of garlic and allium mongolicum regel composition in preparation of antiviral product

Examples

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Effect test

Embodiment 1

[0028] The preparation of embodiment 1 garlic, shallot extract

[0029] (1) Preparation of garlic alcohol extract: take garlic dry powder dried to constant weight and add 90% v / v, 80% v / v, 70% v / v ethanol aqueous solution to reflux extraction for 3 times, filter, and dregs for subsequent use. Combine the extracts, recover the ethanol, and dry to obtain the garlic alcohol extract. The yield of the paste is about 75.13 ± 5%.

[0030] (2) Preparation of garlic water extract: get the medicine dregs in step (1), decoct them with water for 3 times, filter, combine the filtrate, concentrate, and dry to obtain garlic water extract. After determination, the paste yield is about 15.18±2%.

[0031] (3) Preparation of the ethanol extract of shallot: take the dry powder of shallot dried to constant weight and add 90% v / v, 80% v / v, and 70% v / v ethanol aqueous solution to reflux extraction for 3 times, filter, and remove the dregs For later use, the extracts were combined, the ethanol was ...

Embodiment 2

[0033] Embodiment 2 Garlic shallot composition

[0034] Take 5 g of the alcoholic extract of garlic, 1 g of the aqueous extract of garlic, 1.7 g of the alcoholic extract of shallot and 0.5 g of the aqueous extract of shallot prepared in Example 1, and mix them uniformly to obtain the composition of the present invention.

Embodiment 3

[0035] Embodiment 3 Garlic shallot composition

[0036] Take 10 g of garlic alcohol extract, 2 g of garlic water extract, 1.7 g of shallot extract and 0.5 g of water extract of shallot prepared in Example 1, and mix them uniformly to obtain the composition of the present invention.

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Abstract

The invention discloses application of a garlic and allium mongolicum regel composition in preparation of an antiviral product. The composition comprises the following components in parts by weight: 2.5-20 parts of a garlic alcohol extract, 0.5-20 parts of a garlic water extract, 0.7-4.3 parts of an allium mongolicum regel alcohol extract, and 0.5-1 part of an allium mongolicum regel water extract. Replication and propagation of influenza A H1N1 viruses can be effectively inhibited, the inhibition activity is superior to the effect of any single extract, and the composition can be used for preparing products for preventing and / or treating influenza A H1N1 and complications thereof.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of the garlic and shallot composition in the preparation of antiviral products. Background technique [0002] Garlic, the underground bulb of the Allium plant in the family Liliaceae, is rich in protein, oligosaccharides and polysaccharides, as well as fats and minerals. It can be used not only as a seasoning, but also as a medicine. It is a well-known dual-purpose plant for food and medicine. Long-term consumption can play a role in disease prevention and health care. It has various biological activities and is expected to be used in the development of products for the prevention or treatment of various diseases. [0003] Sand onion, also known as Mongolian leek, is a plant of the Liliaceae Allium genus. It grows in deserts, sandy land or dry hillsides at an altitude of 800-2800 meters. In my country, it is mainly distributed in Xinjiang (northeast), Qinghai (...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P31/16
CPCA61K36/8962A61P31/16A61K2300/00
Inventor 王煜伟梁健王乐尹卫张超
Owner QINGHAI UNIVERSITY
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