Ofloxacin eye external composition

A composition for external use, the technology of ofloxacin, which is applied in the directions of drug combination, drug delivery, medical preparations of inactive ingredients, etc., and can solve the problems of corneal cell damage and the like

Pending Publication Date: 2020-11-24
天津道和德生物科技有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The amount of ofloxacin used in this invention patent is not less than 2.245g / L, exceeding the above-mentioned reported mass concentration of 499%, which will inevitably cause certain damage to corneal cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ofloxacin eye external composition
  • Ofloxacin eye external composition
  • Ofloxacin eye external composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Embodiment 1: a kind of ofloxacin eye drops:

[0082] prescription:

[0083]

[0084] Preparation:

[0085] 1) Add co-solvent, ofloxacin, γ-polyglutamic acid, and osmotic pressure regulator to 500mL water for injection, and stir evenly at 90°C and 300r / min;

[0086] 2) Step 1) Add 450mL of water for injection to the mixture, adjust the pH to 6.0-7.0 with a pH regulator, stir at 300r / min and cool to room temperature;

[0087] 3) The mixture in step 2) is adjusted to 1000mL with water for injection, finely filtered through the secondary filter (0.45μm and 0.22μm, pressure 0.1MPa) for 5 times in a grade A environment, and put into a sterile tank. .

Embodiment 2

[0088] Embodiment 2: another kind of ofloxacin eye drops:

[0089] prescription:

[0090]

[0091] The preparation method is the same as in Example 1.

Embodiment 3

[0092] Embodiment 3: a kind of ofloxacin eye drops:

[0093] prescription:

[0094]

[0095] The preparation method is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Kinematic viscosityaaaaaaaaaa
Kinematic viscosityaaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of eye external compositions, in particular to an ofloxacin eye external composition. The ofloxacin eye external composition comprises an effective amountof ofloxacin and gamma-polyglutamic acid, and contains or not contains sodium tanshinol, at least one of a pH regulator, an osmotic pressure regulator, a viscosity regulator, a solubilizer, a cosolvent and an antioxidant and a carrier. In an experiment, the inventor finds that the bacterial inhibition effect of the low-dose ofloxacin can be significantly improved by adding a trace amount of the gamma-polyglutamic acid to the composition, and the cytotoxicity of the high-dose ofloxacin can be significantly inhibited by adding the gamma-polyglutamic acid and the sodium tanshinol according to a specific ratio.

Description

technical field [0001] The invention relates to the technical field of external ophthalmic compositions, in particular to an ofloxacin external ocular composition. Background technique [0002] Eyes are one of the most important organs of the human body, providing protection for people to adapt to social life. In the information age, with the changes in people's lifestyles and working conditions, people spend several times more time with their eyes than in the past few decades, and people increasingly rely on computers, TVs and other video display terminals for various activities , such as working with a computer for a long time, watching TV, playing video games with a PSP or a mobile phone, wearing contact lenses and colored contact lenses, driving for a long time, and mental stress, all of which can easily cause people to suffer from eye fatigue, which in turn causes Eye dryness, eye astringency, eye soreness, blurred vision and even vision loss directly affect people's w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/785A61K31/192A61K9/08A61K47/26A61P31/04A61P27/02
CPCA61K31/785A61K31/192A61K9/0048A61K9/08A61K47/26A61P31/04A61P27/02Y02A50/30
Inventor 姜涛
Owner 天津道和德生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap