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New application of gastrodin in suppressing addiction of opioid drugs

An opioid drug, gastrodin technology, a new application in the treatment of opioid drug addiction, gastrodin preparations and pharmaceutical compositions containing it, gastrodin field, able to solve the research on gastrodin addiction that has not been seen Reporting and other issues

Pending Publication Date: 2020-11-27
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after reviewing relevant domestic and foreign literature, there are only research reports on gastrodin interfering with methamphetamine addiction in rats, but no research reports on the effect of gastrodin on opioid addiction

Method used

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  • New application of gastrodin in suppressing addiction of opioid drugs
  • New application of gastrodin in suppressing addiction of opioid drugs
  • New application of gastrodin in suppressing addiction of opioid drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Oxycodone addiction model experiment

[0016] 1.1 Experimental materials

[0017] 1.1.1 Animals: 10 healthy young DSS (Dahl / Salt sensitive rat) rats aged 7-8 weeks, body weight 180-200 g, provided by Changchun Yisi Experimental Animal Technology, animal license number SCXK (Ji) -2019-0003. Rats were fed with standard feed, free to eat and drink, lighted for 12 hours at 8:00 am every day, kept at room temperature (25 ± 2°C), fasted and water-free during the experiment, and noise interference was avoided.

[0018] 1.1.2 Experimental reagent: oxycodone hydrochloride (Beijing Huasu Pharmaceutical Co., Ltd.).

[0019] 1.1.3 Experimental equipment: conditioned place preference device (Med Associates, USA); self-administration experiment device (modified by conditioned place preference device, including two external drinking water stoppers (one of which is connected to the infusion pump drug delivery device), A series of devices such as lick test water bottle ...

Embodiment 2

[0033] Embodiment 2: Model experiment of rat lateral ventricle microdialysis administration

[0034] 2.1 Experimental materials

[0035] 2.1.1 Animals: Female DSS (Dahl / Salt sensitive rat) rats are the same as "1.1.1". Free to eat and drink, the room temperature was kept at (25 ± 2 ℃), and the light was 12 hours at 8:00 am every day. During the experiment, food and water were fasted and noise interference was avoided.

[0036] 2.1.2 Experimental reagents: Oxycodone hydrochloride (Beijing Huasu Pharmaceutical Co., Ltd.), isoflurane (Wuxi Biome Biotechnology Co., Ltd.), carprofen (Qingdao Kangdien Pharmaceutical Co., Ltd.), en Nofloxacin (Tianjin Ruipu Biological Pharmaceutical Co., Ltd.).

[0037] 2.1.3 Experimental equipment: rat brain stereotaxic instrument (Rivet Life Science Co., Ltd.); dental benchtop electric drill (Shanghai Huanxi Medical Instrument Co., Ltd.); conditioned place preference device (Med Associates, USA); self-administration Experimental device (modified...

Embodiment 3

[0047] Example 3: Intervention experiment of gastrodin on oxycodone-addicted rats

[0048] 3.1 Experimental materials

[0049] 3.1.1 Animals and grouping: 18 healthy young 8-week-old female DSS (Dahl / Salt sensitive rats) rats, weighing 180-200 g, provided by Changchun Yisi Experimental Animal Technology, animal license number SCXK (Ji) -2019-0003. After the oxycodone addiction model, the lateral ventricle microdialysis operation was randomly divided into three groups, 6 rats in each group, which were the control group, the gastrodin low-dose group (50 μg) and the high-dose group (200 μg) . They were all fed with standard feed, free to eat and drink, lighted for 12 hours at 8:00 am every day, kept at room temperature (25 ± 2 ℃), fasted before the experiment and avoided noise interference.

[0050] 3.1.2 Experimental reagents: gastrodin (Shanghai Yuanye Biotechnology Co., Ltd., batch number: B21243, purity ≥ 98%); NaCl, KCl, CaCl 2 , MgCl 2 、Na 2 HPO 4 , NaH 2 PO 4 (Bei...

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Abstract

The invention relates to gastrodin, a gastrodin preparation and a new medical application of a pharmaceutical composition containing the gastrodin preparation in the aspect of treating addiction of opioid drugs. A rat behavioral pharmacology experiment method verifies that the gastrodin has a remarkable anti-oxycodone drug addiction effect. Therefore, the gastrodin can be applied to research and development of anti-addiction drugs through further experimental research.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the new application of gastrodin, a gastrodin preparation and a pharmaceutical composition containing the same in the treatment of opioid drug addiction. Background technique [0002] Due to their definite analgesic effect, opioids are preferred for the treatment of the second and third stages of cancer pain - chronic moderate and severe pain. Common opioids such as morphine, oxycodone, fentanyl, tramadol, etc., the preparations containing oxycodone include paracetamol oxycodone extended-release tablets (Tylerin) and oxycodone hydrochloride extended-release tablets ( OxyContin) is the world's largest selling and most frequently used analgesic drug. Since oxycodone is an opioid μ and κ dual receptor agonist, its addiction-related μ opioid receptor affinity is only 1 / 5~1 / 10 of that of morphine, and its equivalent analgesic effect is 2 times that of morphine. times, so ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/36A23L33/10
CPCA61K31/7034A61P25/36A23L33/10A23V2002/00
Inventor 祝洪艳赵岩刘文丛贾贫慧何忠梅尹莹莹郜玉钢
Owner JILIN AGRICULTURAL UNIV
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