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Genome selection method of residual feed intake of white feather broilers

A technology of white feather broiler, feed intake, applied in the fields of genetic breeding and molecular biology, which can solve the problems of low accuracy, a lot of labor and time

Pending Publication Date: 2020-11-27
INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

RFI phenotyping is labor-intensive and time-intensive, and genetic selection based on phenotype or traditional BLUP estimates is less accurate

Method used

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  • Genome selection method of residual feed intake of white feather broilers
  • Genome selection method of residual feed intake of white feather broilers
  • Genome selection method of residual feed intake of white feather broilers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0140] Example 2 Effect Analysis of 5 SNP Markers on Feed Utilization Efficiency Related Traits

[0141] As shown in Table 5, for the two main feed reward indicators of RFI and average daily feed intake (ADFI), the five significant SNP sites were all significantly different between the homozygous types of the two alleles (P<0.05). The theory is consistent; the traits of body weight and abdominal fat weight are significantly different among groups of different genotypes at some loci; further confirm the association of these 5 SNP markers with RFI.

[0142] 2. Gene expression differential detection

[0143] The phenotype group (n=24) with extremely significant difference in RFI was screened and constructed, and the comparison results between high and low RFI broiler phenotypes are shown in Table 6. There was no significant difference in body weight and average daily gain between high and low RFI broilers (P>0.05). The RFI and FCR of low RFI chickens were significantly lower th...

Embodiment 3

[0153] Example 3 Integrating Significant SNP Markers to Evaluate the Effect of Genomic Selection on Residual Feed Intake of White Feather Broilers

[0154] White-feathered broiler chickens were used to test the population, 1503, which belonged to two generations, 592 and 911 respectively. The phenotype recorded body weight at 28 days, body weight at 42 days, and total feed intake during the growth period at 28 to 42 days. The formula for calculating RFI was as follows:

[0155] ADFI=μ+b 1 hatch+b 2 sex+β 1 MWT+β 2 ADG+e 1

[0156] In the formula, ADFI stands for average daily feed intake, μ stands for intercept, hatch stands for hatching batch, sex stands for sex, MWT stands for mid-test metabolic weight, ADG stands for average daily gain, b 1 and b 2 Represent the effects of batch and gender, respectively, β 1 and beta 2 Represents the partial regression coefficient, e 1 Represents the residual error, that is, RFI, and the unit is g / d.

[0157] In this example, the...

Embodiment 4

[0195] Example 4 Breeding Method for Genomic Selection of Residual Feed Intake in White Feather Broilers Using Integrated Significant SNP Markers

[0196] 1. Establishment of reference population, determination of phenotypic traits and genotype

[0197] Establish an independent reference group for each strain, and the source of the reference group is required to cover all existing families of the strain.

[0198] When the reference group of chickens is close to the market age of 38-42 days of commercial chickens, a group of 2,000-3,000 chickens is established as the reference group. The reference group has clear phenotype records (see Example 3 for methods), pedigree records, blood samples are collected, DNA is extracted, and sent to chicken genome-wide SNP chips for testing. Determine the genotypes of 30,000 to 50,000 SNP sites distributed evenly across the genome. The specific process can be referred to CN111225986A. Determine the results of about 50,000 sites in the whol...

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Abstract

The invention provides a genome selection method of residual feed intake of white feather broilers. GEBV estimation is carried out on the residual feed intake (RFI) of an important feed conversion character index by utilizing a one-step whole-genome breeding value (GEBV) estimation method integrating a remarkable SNP marker effect. The invention further provides an SNP marker remarkably related tothe residual feed intake character of the white feather broiler chicken and application of the SNP marker. The SNP marker comprises the marker rs13649171, the marker rs740268684, the marker rs312607889, the marker rs314437326 and the marker rs313748618. Compared with a conventional one-step GEBV estimation result, the selection accuracy of the breeding method of the white feather broiler chickenline with the low residual feed intake character can be improved by 15.44%. The method can shorten the new strain breeding time, save the breeding cost, improve the breeding efficiency and acceleratethe white feather broiler chicken autonomous strain breeding process in China.

Description

technical field [0001] The invention relates to the fields of genetic breeding and molecular biology, in particular to a genome selection method for residual feed intake of white-feathered broiler chickens. Background technique [0002] China ranks first in the world in broiler slaughter volume and third in output in the world. The annual slaughter of broiler chickens has exceeded 10 billion. Chicken is the second largest meat product in my country, accounting for about 16% of the total meat output, and the proportion is showing an increasing trend year by year. my country's chicken meat mainly comes from the introduction of fast-growing white-feather broilers and local yellow-feather broilers. About 5 billion white-feathered broilers are slaughtered annually, accounting for about 60% of the total chicken output. It has significant advantages such as low feed-to-weight ratio, fast growth speed, and high production efficiency. Since about 70% of broiler production costs are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B25/10G16B20/20
CPCG16B25/10G16B20/20
Inventor 赵桂苹刘冉冉文杰李韦郑麦青冯甫荣
Owner INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
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