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Toner, lysozyme buccal tablet and preparation method of lysozyme buccal tablet
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A technology of toner and lysozyme, which is applied in the field of pharmaceutical processing, can solve the problems of uneven color inside and outside the tablet, affect the uniformity of the tablet, etc., achieve good color uniformity, better color uniformity, and improve dispersibility Effect
Active Publication Date: 2020-12-01
HANGZHOU GUOGUANG PHARMA
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Problems solved by technology
However, in actual operation, the applicant found that the internal and external color of the tablets prepared by the above method is not uniform, and there will be spots on some tablets formed by the uneven color, commonly known as the "blossom" phenomenon, which affects the tablet. Dose uniformity
Method used
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Embodiment 1
[0046] Embodiment 1, a kind of toner, is prepared through the following steps:
[0047] S1. Adding the pigment and purified water to prepare a suspension with a mass fraction of 10%, stirring evenly, to prepare a pigment suspension;
[0048] S2. Weigh the dextrin, atomize the pigment suspension obtained in step S1 at a pressure of 0.1mPa and a flow rate of 700mL / min under normal pressure and spray it on the dextrin, and keep the speed of 8r / s while spraying. Stir the dextrin at a high speed, after the pigment suspension is sprayed, add an additional 2.5g of purified water, continue stirring for 5 minutes until it is formed, and obtain a pigment wet material;
[0049] S3. Dry the wet pigment material in step S2 at a temperature of 75±5° C. in a hot air circulation oven, pulverize it in a pulverizer, and pass through a 120-mesh sieve to obtain a toner.
[0050] Wherein, the pigment is a mixed system of 0.4g β-carotene and 0.1g tartrazine, the amount of purified water added to t...
Embodiment 2
[0051] Embodiment 2, a kind of toner, is prepared through the following steps:
[0052] S1. Add the pigment and purified water to prepare a suspension, stir evenly, and prepare the pigment suspension;
[0053] S2. Weigh the dextrin, atomize the pigment suspension obtained in step S1 at a pressure of 0.2mPa and a flow rate of 1000mL / min under normal pressure and spray it on the dextrin, and keep the speed of 8r / s while spraying. Stir the dextrin at a high speed, after the pigment suspension is sprayed, add an additional 2.5g of purified water, continue stirring for 5 minutes until it is formed, and obtain a pigment wet material;
[0054] S3. Dry the wet pigment material in step S2 at a temperature of 75±5° C. in a hot air circulation oven, pulverize it in a pulverizer, and pass through a 120-mesh sieve to obtain a toner.
[0055] Wherein, the pigment is a mixed system of 0.4g β-carotene and 0.1g tartrazine, the amount of purified water added to the pigment suspension is 5g, an...
Embodiment 3
[0056] Embodiment 3: a toner, the difference from Embodiment 1 is that the pigment is a mixed system of 0.6g β-carotene and 0.2g tartrazine, and the amount of dextrin added is 15g.
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Abstract
The invention relates to the technical field of medicineprocessing, and in particular relates to a toner, a lysozyme buccal tablet and a preparation method of the lysozyme buccal tablet, wherein thetoner is obtained by adding purified water into pigment to prepare pigment suspension, atomizing and spraying the pigment suspension onto dextrin, fully mixing, drying and crushing. The toner can realize uniform dispersion of pigment, is beneficial to improving the uniformity of the colour and luster of the tablet when the tablet is prepared, and reduces the phenomenon of flower tablets. The invention further provides the lysozyme buccal tablet and the preparation method thereof, wherein the toner is used; and the uniformity of the colour and luster of the prepared lysozyme buccal tablet can be improved.
Description
technical field [0001] The application relates to the technical field of pharmaceutical processing, in particular to a toner; the application also relates to a lysozyme buccal tablet and a preparation method of the lysozyme buccal tablet. Background technique [0002] According to the Chinese Pharmacopoeia, a tablet refers to a round or special-shaped sheet-like solid supported by the raw drug and suitable excipients. Among them, most of the tablets are taken orally, buccally, or chewed. In order to improve children's willingness to take tablets, a certain amount of pigment is often added to the tablets to make the tablets have a brighter color. [0003] In the prior art, generally, the pigment is directly added to the raw materials of the tablet for granulation, and the color of the buccal tablet is adjusted through the pigment. For example, the authorized announcement number is CN101829212B, and the Chinese invention patent whose authorized announcement date is August 31...
Claims
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