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Method and system for automatically designing mouse breeding scheme based on Mendel's genetic law

An automatic design and mouse technology, applied in the field of bioinformatics, can solve problems such as high error rate, low efficiency, time-consuming and energy-consuming, and achieve the effects of avoiding wrong results, improving efficiency, and saving labor costs

Pending Publication Date: 2020-12-08
GEMPHARMATECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The basis of the current design of mouse breeding programs is mainly based on Mendel’s genetic laws, which require scientists with many years of experience to conduct purely manual analysis operations, record all possible results and manually arrange and combine them, then analyze and compare each program, and finally screen It takes a lot of time and energy to come up with a better solution, but the accuracy is not guaranteed
Moreover, due to differences in the thinking patterns and experiences of different experts, even if the design schemes have similar effects, there may still be subtle differences, which will cause inconsistencies in the optimal design schemes obtained in different periods or by different experts.
Therefore, the mouse breeding program in the traditional sense needs to be completed by experienced experts, and the selection of the design program cannot be quickly realized, and the traditional method of manual design program has a high error rate and low efficiency

Method used

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  • Method and system for automatically designing mouse breeding scheme based on Mendel's genetic law
  • Method and system for automatically designing mouse breeding scheme based on Mendel's genetic law
  • Method and system for automatically designing mouse breeding scheme based on Mendel's genetic law

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Embodiment 1

[0031] This embodiment provides a method for automatically designing a mouse breeding program based on Mendelian genetic laws, such as figure 1 shown, including the following steps,

[0032] S1. Build a breeding program model, including the type of project, the number of genes contained in each breeding route, identification method, mouse strain background and background mouse age.

[0033] The above information is necessary but not limited to designing a mouse breeding program. Those skilled in the art should know that other information that may be used may also be used as constituent elements of the model.

[0034] Among them, the project types generally include natural breeding, IVF, biological purification, sperm freezing and any combination of the above types.

[0035] The number of genes included in the breeding line is usually 1-2.

[0036] Identification methods include ordinary PCR, sequencing, nested PCR, QPCR, TA cloning, etc.

[0037] Mouse strain backgrounds i...

Embodiment 2

[0063] This embodiment is a system for automatically designing a mouse breeding program based on Mendelian genetic laws, such as Figure 4 As shown, the system includes:

[0064] The information acquisition unit is used to obtain information related to mouse breeding, including project type, gene quantity contained in each breeding route, identification method, mouse strain background, background mouse age, project information, and starting and purpose mouse information .

[0065] The above information is necessary but not limited to designing a mouse breeding program. The meanings and values ​​of various information are introduced in detail in Embodiment 1, and reference may be made to Embodiment 1. Regardless of the type of items pre-stored in the model, the number of genes contained in each breeding line, the identification method, the background of the mouse strain, the age of the background mouse, etc., or the item information that needs to be input by the operator and ...

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Abstract

The invention provides a method and system for automatically designing a mouse breeding scheme based on the Mendel's genetic law. The method comprises the steps of building a breeding scheme model which comprises a project type, the number of genes contained in each breeding route, an identification mode, a mouse strain background and a background mouse age; inputting item information and startingand target mouse information, and generating at least one feasible breeding scheme, wherein the breeding scheme at least comprises the breeding route and required cost; and selecting and determiningthe breeding scheme. According to the method, the mouse breeding scheme design process and logic based on the Mendel's genetic law are immobilized and standardized and can be sorted according to certain logic, result errors caused by errors of designers can be avoided, and the optimal scheme is derived. The automatic design greatly improves the design efficiency of the breeding scheme, and can save a large amount of labor cost.

Description

technical field [0001] The invention relates to the technical field of biological information, in particular to a method and system for automatically designing a mouse breeding program based on Mendel's genetic law. Background technique [0002] Mendel's laws of inheritance include two basic laws of genetics - the law of segregation and the law of free assortment, collectively referred to as Mendel's laws of inheritance. [0003] Law of segregation: In biological somatic cells, the genetic factors controlling the same trait exist in pairs and do not fuse; when gametes are formed, the paired genetic factors separate, and the separated genetic factors enter different gametes respectively, and then The phenomenon that gametes are passed on to offspring is called Mendel's law of segregation. [0004] The law of free combination is one of the three basic laws of modern biological genetics. When two (or more) pairs of relative traits are crossed and gametes are produced in the o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 罗天同王梦阳
Owner GEMPHARMATECH CO LTD
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