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Preparation method of 6-hydroxyhexanoic acid

A technology of hydroxycaproic acid and acid adjustment, which is applied in the field of preparation of 6-hydroxycaproic acid, can solve complex problems and achieve the effects of fast reaction progress, simple separation process and high yield

Inactive Publication Date: 2020-12-11
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method adds a solvent during the hydrolysis process, which is more complicated in the subsequent treatment

Method used

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  • Preparation method of 6-hydroxyhexanoic acid
  • Preparation method of 6-hydroxyhexanoic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put 10g of poly-6-hydroxycaproic acid, 120g of water, and 2.98g of NaOH into a 250ml distillation flask at one time, put the flask into an oil bath, stir and heat to 100°C with a DF-101S collector type constant temperature heating magnetic stirrer , under the pressure of 0.1MPa constant temperature reaction 2h, followed by 0.1mol / L of H 2 SO 4 The pH value of the solution is adjusted between 3-6, and the temperature is 100° C., and the pressure is -0.03 MPa to distill and dehydrate. The yield of 6-hydroxycaproic acid was 94.3%.

Embodiment 2-11

[0029] Others are the same as Example 1, and the differences are shown in the following table.

[0030]

[0031]

[0032] As can be seen from the table, the hydrolysis rate of the poly-6-hydroxycaproic acid of the present invention reaches more than 92%.

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Abstract

The invention provides a preparation method of 6-hydroxyhexanoic acid. The preparation method comprises the step of hydrolyzing poly 6-hydroxyhexanoic acid or a 6-hydroxyhexanoic acid oligomer under an alkaline condition. Alkaline hydrolysis adopted in the invention has the following beneficial effects: (1) the yield is high; (2) the conditions are not harsh; (3) the reaction progress is fast; and(4) the separation is simple.

Description

technical field [0001] The invention belongs to the chemical industry, in particular to the field of synthesis of 6-hydroxycaproic acid, in particular to a preparation method of 6-hydroxycaproic acid. Background technique [0002] Polycaprolactone (referred to as PCL) is formed by ring-opening polymerization of ε-caprolactone under the condition of a metal-organic compound (such as tetraphenyltin) as a catalyst and dihydroxyl or trihydroxyl as an initiator. Esters, their molecular weight and degree of disproportionation vary with the type and amount of starting materials. It has good biocompatibility, biodegradability, good solvent solubility, crystallinity and low melting point, and has a wide range of applications in the field of biomedicine and environmental protection materials, and 6-hydroxycaproic acid can be prepared by intramolecular condensation Caprolactone, caprolactone is a chemical intermediate for preparing polycaprolactone, therefore, it is very important for...

Claims

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Application Information

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IPC IPC(8): C07C51/09C07C51/44C07C59/01
CPCC07C51/09C07C51/44C07C59/01
Inventor 谢传欣
Owner QINGDAO UNIV OF SCI & TECH
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