Method for preparing carboxylic acid by green catalytic oxidation of aliphatic primary alcohol
A catalytic oxidation and aliphatic technology, applied in chemical instruments and methods, preparation of organic compounds, catalytic reactions, etc., can solve the problems of complex catalyst preparation process, numerous reaction by-products, and difficulty in recycling, and achieve good industrial application prospects , less reaction time, good catalytic effect
Examples
Embodiment 1
[0038] The green catalytic oxidation reaction method of aliphatic primary alcohol in the present embodiment, the steps of this method are:
[0039] Add 10mL of acetonitrile, 1.4445g of isononyl alcohol, 0.3271g of NHPI, and 0.3846g of copper oxide into the three-necked flask in turn, then feed oxygen at 20mL / min under normal pressure, stir at 70°C for 12h, and finally detect and analyze by GC. The yield of isononanoic acid was 83.72%.
[0040] Wherein the proportioning of used isononanol and acetonitrile is calculated according to the molar volume ratio, i.e. isononanol: acetonitrile is 1mol: 1000mL; The ratio of nonanol is 0.2:0.48:1; the oxygen flow rate is calculated as 2000mL / min per 1 mol of isononanol.
Embodiment 2
[0044] A kind of green catalytic oxidation reaction method of aliphatic primary alcohol, the steps of this method are:
[0045] Add 15mL of acetonitrile, 1.0221g of 1-hexanol, 0.3262g of NHPI, and 0.3850g of copper oxide into the three-necked flask in sequence, then feed oxygen at 20mL / min under normal pressure, stir at 70°C for 6 hours, and finally determine the final concentration by GC detection. The product was 1-hexanoic acid, and the solvent acetonitrile was distilled off with a rotary vacuum evaporator, and the yield of 1-hexanoic acid was calculated to be 56.63%.
[0046] The ratio of 1-hexanol and acetonitrile used is calculated according to the molar volume ratio, that is, 1-hexanol: acetonitrile is 1mol:1500mL; Copper: 1-hexanol is 0.2:0.48:1; the oxygen flow rate is calculated as 2000mL / min per 1 mol of 1-hexanol.
Embodiment 3
[0048] A kind of green catalytic oxidation reaction method of aliphatic primary alcohol, the steps of this method are:
[0049] Add 10mL of acetonitrile, 1.3028g of n-octanol, 0.3271g of NHPI, and 0.3852g of copper oxide in the three-necked flask in sequence, then feed oxygen at 20mL / min under normal pressure, stir at 70°C for 24h, and finally detect and analyze by GC. The oxidation product is n-octanoic acid, and the yield of n-octanoic acid is 90.25%.
[0050] Wherein the proportioning of used n-octanol and acetonitrile is calculated according to the molar volume ratio, namely n-octanol: acetonitrile is 1mol: 1500mL; The ratio of octanol is 0.2:0.48:1; the oxygen flow rate is calculated as 2000mL / min per 1 mol of n-octanol.
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