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Preparation process and quality control method of poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference

A quality control method and technology of preparation process, which are applied in measurement devices, resistance to vector-borne diseases, instruments, etc., can solve the problem of preparation technology and quality research methods without full control means, and without a system that fully reflects the types of chemical components and material transfer Sexual research reports and other issues, to achieve good stability and repeatability

Active Publication Date: 2020-12-15
JIANGSU KANION PHARMA CO LTD
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, there is no whole-process control method for the preparation process and quality research method of the substance standard of Lingguizhugan Decoction, and there is no systematic research report that fully reflects the types of chemical components and substance transfer contained in the various flavors of this classic prescription.

Method used

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  • Preparation process and quality control method of poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference
  • Preparation process and quality control method of poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference
  • Preparation process and quality control method of poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference

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Embodiment 1

[0069] 1. Study on the preparation process of Lingguizhugan Decoction substance standard

[0070] 1.1 Determination of prescription composition and decoction volume

[0071] The prescription amount, usage and dosage information of the Linggui Zhugan Decoction adopted by the present invention through textual research is the same as that listed in the "Key Information Table of Ancient Classical Prescriptions (7 Prescriptions) (Draft for Soliciting Comments)" issued by the State Administration of Traditional Chinese Medicine. The prescription information is consistent, that is, the prescription composition is: Poria cocos 55.2g, Guizhi 41.4g, Atractylodes macrocephala 41.4g and licorice 27.6g, add water 1200mL, decoct to 600mL.

[0072] 1.2 Index selection of extraction process

[0073] In "Chinese Pharmacopoeia" (2015 edition), there are no quantitative indicators under Poria cocos and Atractylodes macrocephala, the quantitative indicators under cassia twig are cinnamic aldehyd...

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Abstract

The invention relates to a preparation process and a quality control method of a poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference. According to the invention, through systematic historical research on prescriptions, an ancient method and a modern extraction method are combined, single factor investigation is adopted, and a preparation process and adrying process of the poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction and the material reference thereof are optimized. Furthermore, poria cocos, cassia twig, bighead atractylodes rhizome and liquorice in the material reference are identified by adopting thin-layer chromatography, a fingerprint spectrum with good separation degree and reproducibility is established by adopting high performance liquid chromatography, and liquiritin, cinnamic acid and cinnamaldehyde are quantitatively researched by adopting the high performance liquid chromatography. According to the established preparation process and the quality standard research method of the poria cocos, cassia twig, bighead atractylodes rhizome and liquorice decoction material reference, a systematic research basis is provided for reasonable development of the compound preparation.

Description

technical field [0001] The invention relates to the field of medicine preparation and quality control thereof, in particular to a preparation process of Linggui Zhugan Decoction substance reference and a quality control method thereof. Background technique [0002] Linggui Zhugan Decoction has already been prepared, decocted and taken in pieces in "Treatise on Febrile Diseases" and "Synopsis of the Golden Chamber", but the decoction conditions in ancient books are mostly general, so it should be done according to the records in ancient books and according to the current decoction habits, for example Soaking time, extraction times, etc. were investigated to simulate the preparation methods of ancient decoctions; in the research of modern preparations, the preparation process and the composition and content of chemical components in the preparations should be considered as consistent as possible with traditional decoctions to ensure the safety and effectiveness of modern prepar...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/86G01N30/06
CPCG01N30/02G01N30/06G01N30/8686Y02A50/30
Inventor 肖伟季光李玲王冰顾思浩吴伟张彤
Owner JIANGSU KANION PHARMA CO LTD
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