A kind of external gel for skin wound and preparation method thereof

A technology for external use of gels and skin wounds, which is applied in the directions of skin diseases, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. , granular dispersed solid sedimentation and other problems, to achieve the effects of good stability and uniformity, reduction of wound healing days, and simple preparation method

Active Publication Date: 2021-08-06
SHANDONG RUIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the pharmaceutical preparations for the treatment of skin wounds are ointments, and their auxiliary ingredients are mainly vaseline and liquid paraffin. In the case of high temperature (> 38 ℃), vaseline will gradually dissolve, and the granular dispersed solids will appear to settle, which will affect the uniformity and use effect of the ointment

Method used

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  • A kind of external gel for skin wound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Preparation of an external gel for skin wounds

[0047] 1. Composition of raw materials (by weight):

[0048] 2 parts of active component A, 5 parts of active component B, 12 parts of calendula extract, 18 parts of centella asiatica extract, 63 parts of excipients; including:

[0049] The active component A is formed by mixing polymyxin B sulfate, neomycin sulfate and bacitracin in a mass ratio of 0.65:5.36:7.7; the polymyxin B sulfate is 50000 units / branch, and the Neomycin sulfate is 35000 units / support, and the bacitracin is 5000 units / support.

[0050]The active component B is formed by mixing lidocaine hydrochloride and menthol at a mass ratio of 1:1.

[0051] The calendula extract is prepared by the following method:

[0052] Dry and pulverize Calendula officinalis, extract 3 times with 10 times by weight of ethanol with a volume concentration of 95%, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are combi...

Embodiment 2

[0062] Embodiment 2: the preparation of the external gel for skin wound

[0063] 1. Composition of raw materials (by weight):

[0064] 1 part of active component A, 6 parts of active component B, 10 parts of calendula extract, 20 parts of centella asiatica extract, 60 parts of excipients; including:

[0065] The active component A is mixed by polymyxin B sulfate and neomycin sulfate in a mass ratio of 0.65:5.36; the polymyxin B sulfate is 50000 units / support, and the neomycin sulfate is 35000 units / piece.

[0066] The active component B is pramoxine hydrochloride.

[0067] The calendula extract is prepared by the following method:

[0068] Dry and pulverize Calendula officinalis, extract 4 times with 8 weight times of ethanol with a volume concentration of 95%, the extraction temperature is 70°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 -1.2 (measured at 50°C), to obtain alcoholic ex...

Embodiment 3

[0076] Embodiment 3: the preparation of the external gel for skin wound

[0077] 1. Composition of raw materials (by weight):

[0078] 3 parts of active component A, 4 parts of active component B, 14 parts of calendula extract, 16 parts of centella asiatica extract, 60 parts of excipients; of which:

[0079] The active component A is formed by mixing neomycin sulfate and bacitracin at a mass ratio of 5.36:7.7; the neomycin sulfate is 35,000 units per branch, and the bacitracin is 5,000 units per branch.

[0080] The active component B is formed by mixing procaine hydrochloride and menthol at a mass ratio of 1:1.

[0081] The calendula extract is prepared by the following method:

[0082] Dry and pulverize Calendula officinalis, extract twice with 95% ethanol with a volume concentration of 9 times the weight, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 ...

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Abstract

The invention discloses an external gel for skin wounds, which is made of the following raw materials in parts by weight: 1-3 parts of active component A, 4-6 parts of active component B, 10-10 parts of calendula extract 14 parts, 16-20 parts of Centella asiatica extract, 60-80 parts of auxiliary materials; the active component A is at least two of polymyxin B sulfate, neomycin sulfate and bacitracin; the active component Part B is at least one of lidocaine hydrochloride, pramoxine hydrochloride, procaine hydrochloride and menthol; the auxiliary materials include the following raw materials in parts by weight: 0.5-3 parts of carbomer, organic solvent 40‑75 parts, 20‑50 parts of purified water. The gel for external use of the present invention has a preventive effect on bacterial infection of skin wounds, and has analgesic and hemostatic effects on skin wounds; it can also promote the formation of wound capillaries and collagen fibers, reduce the days of wound healing, and can be used for burns, cuts, For the healing of skin wounds such as burns, the healed skin is smooth, without scars, and the healing effect is good.

Description

[0001] 1. Technical field [0002] The invention relates to the technical field of pharmaceutical preparations, in particular to an external gel for skin wounds and a preparation method thereof. [0003] 2. Background technology [0004] Skin is an important organ of the human body, composed of epidermis and dermis, and has important physical, chemical and biological barrier functions. Burns, cuts, and scalds are common skin wounds in peacetime and wartime; various damages caused by skin trauma, such as: increased metabolism, decreased body temperature, excessive loss of water and protein, and disorders of the endocrine and immune systems are all related to the skin barrier. related to loss of function. [0005] Wound healing is a complex biological process, including cell proliferation, differentiation, epithelialization, migration, and matrix synthesis and deposition. In clinical practice, skin wounds are often treated by speeding up wound healing, preventing bacterial infe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/12A61K9/06A61K47/10A61P17/02A61P31/02A61P31/04A61K31/7036A61K31/167A61K31/535A61K31/245A61K31/045A61K36/28
CPCA61K9/0014A61K9/06A61K31/045A61K31/167A61K31/245A61K31/535A61K31/7036A61K36/23A61K36/28A61K38/12A61K47/10A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61P17/02A61P31/02A61P31/04A61K2300/00
Inventor 张焕刘宗银钱林艺曹慧敏
Owner SHANDONG RUIAN PHARMA CO LTD
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