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Application of ACTRT1 as target in detection and treatment of acephalic spermatozoa (AS)

A sperm, target technology, applied in the biological field

Pending Publication Date: 2020-12-29
THE FIRST AFFILIATED HOSPITAL OF JINZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above prior art reports, SUN5 and PMFBP1 gene mutations do not affect the outcome of IVF assisted pregnancy, while TSGA10, BRDT, and CEP112 gene mutations may affect the outcome of IVF assisted pregnancy

Method used

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  • Application of ACTRT1 as target in detection and treatment of acephalic spermatozoa (AS)
  • Application of ACTRT1 as target in detection and treatment of acephalic spermatozoa (AS)
  • Application of ACTRT1 as target in detection and treatment of acephalic spermatozoa (AS)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Establish a headless spermatozoa sample bank with sufficient sample sources

[0032] After 13 years of accumulation, more than 100 blood samples (sample number LYZ20061001-LSK201901016115) from patients with teratozoospermia such as partial or all headless sperm, partial or all short-tailed sperm, and round-headed sperm were collected, including 25 headless sperm samples.

[0033] 2) The clinical data of an independent family sample with cephalospermia were found earlier

[0034] Found 1 independent non-consanguineous nuclear family sample of ancephalospermia (sample number SXX2019092101) (see figure 2). Specifically, the patient (II: 1), 33 years old, has a normal sexual life after marriage, 2-3 times / week, and the woman has a spontaneous abortion once to visit the doctor. Normal life, no bad habits, no history of trauma and surgery, no history of exposure to toxic substances, parents are non-consanguineous and bred 1 child, height 177cm, weight 76kg, no abnormal...

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Abstract

The invention discloses application of ACTRT1 as a target in detection and treatment of acephalic spermatozoa (AS). In the invention, ACTRT1 gene mutation causes ACTRT1 functional protein deletion, possibly affects head-to-tail connection of sperm, and finally induces AS.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of ACTRT1 as a target in the detection and treatment of cephalospermia. Background technique [0002] In recent years, the problem of infertility in new-born families in my country has become increasingly serious, causing serious mental pressure and population strategic pressure on the family and society. From a long-term perspective, it is not conducive to the sustainable development of our society. At present, the incidence of infertility in my country is about 15%, and about half of them are male factors. As an important reproductive organ in men, the testis is responsible for sperm development and secretion of male sex hormones. There are many factors that lead to male infertility, and spermatogenesis disorder is one of the important reasons, including but not limited to azoospermia, oligospermia, asthenozoospermia, teratozoospermia, and a combination...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883A61K45/00A61P15/08
CPCA61K45/00A61P15/08C12Q1/6883C12Q2600/156
Inventor 沙艳坤钟震海郑宇李琳
Owner THE FIRST AFFILIATED HOSPITAL OF JINZHOU MEDICAL UNIV
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