Crystal form of isoquinoline compound and preparation method of crystal form
A crystal form and diffraction peak technology, applied in the field of medicinal chemistry, can solve problems such as high energy consumption, long cycle time, and difficult process control in industrial production
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Embodiment 1
[0171] Embodiment 1: the preparation of crystal form A
[0172] Mix 0.5g of roxadustat sample with 30mL of solvent mixed with acetone / water=3:1 by volume to dissolve all the sample, and let it stand at room temperature to evaporate the solvent to obtain a crystalline solid, which is crystal form A, purity 99.1%. Its X-ray diffraction pattern is as figure 1 shown.
Embodiment 2
[0173] Embodiment 2: the preparation of crystal form B
[0174] Mix 1 g of roxadustat sample with 50 ml of a solvent mixed with ethanol / water = 4:1 by volume to dissolve all the sample, and evaporate the solvent to dryness at room temperature to obtain a crystalline solid, which is Form B with a purity of 99.2%. Its X-ray diffraction pattern is as figure 2 shown.
Embodiment 3
[0175] Embodiment 3: the preparation of crystal form C
[0176] Mix 1g of roxadustat sample with 10ml of solvent mixed with acetone / water=3:1 by volume, heat to 55°C under magnetic stirring conditions, until the sample is completely dissolved, and rapidly cool down to 5°C at a rate of 20°C / h. ℃, kept stirring for 6 hours, and filtered to obtain 0.89 g of a crystal form C sample with a purity of 99.5%.
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