Pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and preparation method of pharmaceutical composition
A composition, hand-foot-mouth technology, applied in antiviral agents, pharmaceutical formulations, plant raw materials, etc., can solve the problems of respiratory and digestive tract symptoms, drug resistance, long treatment cycle, etc., and achieve less wound irritation , short treatment time and simple preparation method
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Embodiment 1
[0055] Embodiment 1: the preparation of iodized chitosan
[0056] The method is as follows: (1) Disperse 30g of chitosan and 86.52g of iodine in 1000ml of acetic acid, and stir at 50°C for 12 hours. Under the conditions of a temperature of 60° C. and a pressure of 10 kPa, the concentrated solution A was obtained by distillation under reduced pressure to a quarter of the original volume. The concentrated solution A was dissolved with 20 times the volume of dichloromethane, neutralized to pH=7 by adding saturated aqueous sodium bicarbonate solution dropwise, dried with anhydrous sodium sulfate, and filtered to obtain the filtrate B. Under the conditions of a temperature of 50° C. and an air pressure of 10 kPa, the filtrate B was distilled under reduced pressure to one-fifth of the original volume to obtain a concentrated solution C. The concentrate C was dissolved in 4 times the amount of methanol, and crystallized at 2° C. for 12 hours to obtain 56.5 g of iodized chitosan.
Embodiment 2
[0057] Embodiment 2: the preparation of pharmaceutical composition
[0058] Add 20g of Hedyotis diffusa, 15g of Leucorrhizae, 8g of cress, 5g of herb, 3g of Chinese yam, 5g of licorice and 10 times the amount of distilled water in a 1000ml flask, stir evenly, heat to 95°C, and reflux at this temperature for 3 After hours, the filter residue was removed by filtration to obtain filtrate D. Mix the filter residue and 10 times the amount of distilled water evenly, heat to 95° C., and reflux at this temperature for 3 hours, remove the filter residue by filtration, and obtain filtrate E. Combine filtrate D and filtrate E, and distill the filtrate under reduced pressure to one-third of the original volume at a temperature of 50°C and an air pressure of 10kPa, cool to 2°C, place for 12 hours, and filter to remove insoluble matter. Filtrate F is obtained. Add 1 times the amount of distilled water and 3 g of iodized chitosan to the filtrate F, stir evenly to obtain the pharmaceutical ...
Embodiment 3
[0059] Embodiment 3: the preparation of pharmaceutical composition
[0060] Add 25g of Hedyotis diffusa, 12g of Leucorrhizae, 5g of cress, 6g of herb, 5g of Chinese yam, 7g of licorice and 10 times the amount of distilled water in a 1000ml flask, stir evenly, heat to 95°C, and reflux at this temperature for 3 After hours, the filter residue was removed by filtration to obtain filtrate D. Mix the filter residue and 10 times the amount of distilled water evenly, heat to 95° C., and reflux at this temperature for 3 hours, remove the filter residue by filtration, and obtain filtrate E. Combine filtrate D and filtrate E, and distill the filtrate under reduced pressure to one-third of the original volume at a temperature of 50°C and an air pressure of 10kPa, cool to 2°C, place for 12 hours, and filter to remove insoluble matter. Filtrate F is obtained. Add 1 times the amount of distilled water and 2 g of iodized chitosan to the filtrate F, stir evenly to obtain the pharmaceutical ...
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