Pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and preparation method of pharmaceutical composition

A composition, hand-foot-mouth technology, applied in antiviral agents, pharmaceutical formulations, plant raw materials, etc., can solve the problems of respiratory and digestive tract symptoms, drug resistance, long treatment cycle, etc., and achieve less wound irritation , short treatment time and simple preparation method

Inactive Publication Date: 2021-01-15
中瑞康安科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral drugs such as acyclovir and ribavirin commonly used in clinical practice have disadvantages such as long treatment cycle, respiratory and gastrointestinal symptoms, and drug resistance.

Method used

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  • Pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and preparation method of pharmaceutical composition
  • Pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and preparation method of pharmaceutical composition
  • Pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the preparation of iodized chitosan

[0056] The method is as follows: (1) Disperse 30g of chitosan and 86.52g of iodine in 1000ml of acetic acid, and stir at 50°C for 12 hours. Under the conditions of a temperature of 60° C. and a pressure of 10 kPa, the concentrated solution A was obtained by distillation under reduced pressure to a quarter of the original volume. The concentrated solution A was dissolved with 20 times the volume of dichloromethane, neutralized to pH=7 by adding saturated aqueous sodium bicarbonate solution dropwise, dried with anhydrous sodium sulfate, and filtered to obtain the filtrate B. Under the conditions of a temperature of 50° C. and an air pressure of 10 kPa, the filtrate B was distilled under reduced pressure to one-fifth of the original volume to obtain a concentrated solution C. The concentrate C was dissolved in 4 times the amount of methanol, and crystallized at 2° C. for 12 hours to obtain 56.5 g of iodized chitosan.

Embodiment 2

[0057] Embodiment 2: the preparation of pharmaceutical composition

[0058] Add 20g of Hedyotis diffusa, 15g of Leucorrhizae, 8g of cress, 5g of herb, 3g of Chinese yam, 5g of licorice and 10 times the amount of distilled water in a 1000ml flask, stir evenly, heat to 95°C, and reflux at this temperature for 3 After hours, the filter residue was removed by filtration to obtain filtrate D. Mix the filter residue and 10 times the amount of distilled water evenly, heat to 95° C., and reflux at this temperature for 3 hours, remove the filter residue by filtration, and obtain filtrate E. Combine filtrate D and filtrate E, and distill the filtrate under reduced pressure to one-third of the original volume at a temperature of 50°C and an air pressure of 10kPa, cool to 2°C, place for 12 hours, and filter to remove insoluble matter. Filtrate F is obtained. Add 1 times the amount of distilled water and 3 g of iodized chitosan to the filtrate F, stir evenly to obtain the pharmaceutical ...

Embodiment 3

[0059] Embodiment 3: the preparation of pharmaceutical composition

[0060] Add 25g of Hedyotis diffusa, 12g of Leucorrhizae, 5g of cress, 6g of herb, 5g of Chinese yam, 7g of licorice and 10 times the amount of distilled water in a 1000ml flask, stir evenly, heat to 95°C, and reflux at this temperature for 3 After hours, the filter residue was removed by filtration to obtain filtrate D. Mix the filter residue and 10 times the amount of distilled water evenly, heat to 95° C., and reflux at this temperature for 3 hours, remove the filter residue by filtration, and obtain filtrate E. Combine filtrate D and filtrate E, and distill the filtrate under reduced pressure to one-third of the original volume at a temperature of 50°C and an air pressure of 10kPa, cool to 2°C, place for 12 hours, and filter to remove insoluble matter. Filtrate F is obtained. Add 1 times the amount of distilled water and 2 g of iodized chitosan to the filtrate F, stir evenly to obtain the pharmaceutical ...

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Abstract

The invention discloses a pharmaceutical composition capable of inhibiting hand-foot-and-mouth viruses and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight of 1-5 parts of chitosan iodide, 15-30 parts of herba hedyotis, 10-25 parts of cardamine hirsuta linn, 2-10 parts of cress, 2-10 parts of rhizomaatractylodis, 2-8 parts of rhizoma dioscoreae and 2-8 parts of radix glycyrrhizae. The preparation method comprises the following steps of adding the herba hedyotis, the cardamine hirsuta linn, the cress, the rhizoma atractylodis, the rhizoma dioscoreae, the radix glycyrrhizae and distilled water into a container, performing stirring and heating, performing refluxing for 3 hours, and performing filtration to obtain a filtrate D; uniformly mixing filter residues with the distilled water, performing heating, performing refluxing for 3 hours, and performing filtration to obtain a filtrate E; combining the filtrate D and the filtrate E, distilling the filtrate under reduced pressure until the volume is 1 / 3 of the original volume, and performing cooling, standing and filtration to obtain a filtrate F; and adding the distilled water and the chitosan iodide into the filtrate F, and performing uniform stirring to obtain the pharmaceutical composition. The pharmaceutical composition capable ofinhibiting the hand-foot-and-mouth viruses has the characteristics of outstanding curative effect, stable formula, small side effect and convenience in use.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition capable of inhibiting hand-foot-mouth virus and a preparation method thereof. Background technique [0002] Hand, foot and mouth disease is a common infectious disease caused by a variety of enteroviruses (EV71, CVA16, etc.). It is mainly characterized by fever and rashes or herpes on the hands, feet, and mouth. Most patients will have fever when they get onset, accompanied by symptoms such as headache, cough, and runny nose. The course of disease is long and the patients are very painful. At present, there is no specific treatment for HFMD, and antiviral and symptomatic treatment are the main treatments. Antiviral drugs such as acyclovir and ribavirin commonly used in clinical practice have disadvantages such as long treatment cycle, respiratory and gastrointestinal symptoms, and drug resistance. [0003] Iodized chitosan is structurally modified fro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P31/14A61K31/722
CPCA61K31/722A61K36/23A61K36/284A61K36/484A61K36/748A61K36/88A61K36/8945A61K2236/331A61K2236/39A61P31/14A61K2300/00
Inventor 黄弘昊王卫华
Owner 中瑞康安科技发展有限公司
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