A ligament regeneration scaffold with gradient-induced activity and its preparation method

A technology for inducing activity and ligaments, applied in the direction of stents, devices coated with liquid on the surface, braids, etc., to achieve the effects of improving stability, improving load capacity, and avoiding fatigue failure

Active Publication Date: 2021-11-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, based on the inorganic coating material uniformly distributed in the substrate body, which can be slowly released through the healing cycle, and maintains good structural stability during the slow release process of degradation, a highly stable ligament regeneration scaffold with gradient-induced activity has not been reported.

Method used

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  • A ligament regeneration scaffold with gradient-induced activity and its preparation method
  • A ligament regeneration scaffold with gradient-induced activity and its preparation method
  • A ligament regeneration scaffold with gradient-induced activity and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A preparation method of a ligament regeneration scaffold with gradient-induced activity:

[0049] Step 1: Prepare multi-component degradable composite yarn: adopt two-way weaving molding process, use PCL monofilament 3-a for the shell yarn, and PGCL monofilament 3-b for the core yarn, and obtain the front and back of PCL monofilament wrapped around PGCL monofilament Symmetrically interlaced, PCL monofilament two-up and two-down interlaced biodegradable composite yarn for use, such as image 3 shown;

[0050] Step 2: Prepare the stent preform: adopt the machine-woven integrated molding technology, use PGCL yarn for the warp, and use the degradable composite yarn obtained in step 1 for the weft, and carry out weaving on the machine to obtain the stent preform;

[0051] Step 3: Wash the stent prefabricated body prepared in Step 2 with 75% ethanol, then dry it at 37°C, and set aside;

[0052] Step 4: Gradient impregnation-hot melt treatment: add 50 mg of nano-hydroxyapati...

Embodiment 2

[0056] Step 1: Prepare multi-component degradable composite yarn: adopt three-way weaving molding process, select PLLA monofilament 4-a as the braiding yarn, and introduce PPDO monofilament 4-b as the shaft yarn at the same time to obtain PLLA monofilament two The degradable composite yarn with double interweaving and PPDO interweaving along the axial direction of the degradable composite yarn, such as Figure 4 shown;

[0057] Step 2: Preparing the scaffold preform: using the machine-woven integrated molding technology, the warp yarn is made of PLLA monofilament, the weft yarn is made of the degradable composite yarn obtained in step 1 and the PLLA monofilament is arranged according to the ratio of 1:1, and the weaving is carried out on the machine to obtain Stent preform;

[0058] Step 3: Wash the stent prefabricated body prepared in Step 2 with 75% ethanol, then dry it at 37°C, and set aside;

[0059] Step 4: Gradient impregnation-hot-melt treatment: Add 1 g of nano-β-TCP...

Embodiment 3

[0063] Step 1: Prepare multi-component degradable composite yarn: adopt twisting molding process, use PCL monofilament 5-a for shell yarn, and PLLA monofilament 5-b for core yarn, and obtain PCL monofilament wrapped around PLLA monofilament in the shape of "S "Twist-coated biodegradable composite yarns, such as Figure 4 shown;

[0064] Step 2: Prepare the scaffold preform: adopt the weaving integrated molding technology, the loading ratio of PLLA monofilament and degradable composite yarn is 3:1, and carry out weaving on the machine to obtain the scaffold preform;

[0065] Step 3: Wash the stent prefabricated body prepared in Step 2 with 75% ethanol, then dry it at 37°C, and set aside;

[0066] Step 4: Gradient impregnation-hot-melt treatment: Add 5 g of mesoporous bioglass (MBG) particles into 100 mL of deionized water and disperse ultrasonically for 60 minutes to obtain MBG solution; place the scaffold preformed bone tunnel segment obtained in step 3 in Immerse in MBG sol...

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Abstract

The invention discloses a ligament regeneration scaffold with gradient inducing activity and a preparation method thereof. The stent includes a tendon / ligament soft tissue segment, a transition segment, and a bone tunnel segment from the middle to both sides along the length direction; the stent is woven from a degradable composite yarn or a degradable single-component yarn, and Gradient-induced coatings with different concentrations of inorganic active ingredients are obtained in the bone tunnel segment and transition segment by gradient dipping-hot-melt treatment, and at the same time, regular bonding and reinforcement are formed in the bone tunnel segment; the degradable composite yarn is composed of at least two melting points Woven from different yarns. The preparation method comprises the steps of preparing degradable composite yarn, preparing scaffold preform, washing and drying, gradient impregnation-hot melt treatment, washing and drying, sterilization and the like. The invention can be used for regeneration and reconstruction treatment of ligament / tendon / rotator cuff.

Description

technical field [0001] The present invention relates to a ligament regeneration scaffold for ligament / tendon / rotator cuff reconstruction and repair and its preparation method, in particular to a highly stable ligament regeneration scaffold with gradient-induced activity and its preparation method, which belongs to the preparation technology of biomedical textiles field. Background technique [0002] The anterior cruciate ligament is an important ligament structure in the human knee joint. It is surrounded by synovial tissue and connects the femur and tibia. Joint stability. ACL injuries are often caused by complex and sudden stresses during everyday activities and sports. The anterior cruciate ligament is a dense connective tissue with limited vascularization, and it is difficult to endogenously heal after injury. Therefore, 85% of ACL tears require surgical reconstruction. [0003] Commonly used grafts for ACL reconstruction include tendon autografts, tendon allografts, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D03D1/00D03D11/02D03D15/292D03D15/47D04C1/02D04C1/06D06C7/00D02G3/22B05D7/24B05D5/00
CPCB05D5/00B05D7/24D02G3/22D03D1/00D03D11/02D03D15/00D04C1/02D04C1/06D06C7/00D10B2509/06
Inventor 王璐谢晓静林婧乔峰关国平王富军管晓宁丁丹枝胡亚歌
Owner DONGHUA UNIV
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