Preparation method of 2-hydroxyethyl urea

A technology of hydroxyethyl urea and oxazolidinone, which is applied in the field of preparation of 2-hydroxyethyl urea, can solve the problems of reducing product quality, complicated reaction system and the like, and achieves the effect of high product quality

Pending Publication Date: 2021-01-19
禹城禹圳生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are two disadvantages in the above-mentioned technique: 1) the reaction system is complicated, and the yield of the target product 2-hydroxyethylurea is less than 50%, while the yield of the main by-product 2-oxazolidinone reaches 35-40% ; 2) Most manufacturers simply remove ammonia and water and sell them as 50% finished products, but in fact the solid content of 2-hydroxyethylurea is less than 25%, seriously reducing product quality

Method used

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  • Preparation method of 2-hydroxyethyl urea
  • Preparation method of 2-hydroxyethyl urea
  • Preparation method of 2-hydroxyethyl urea

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Experimental program
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Effect test

Embodiment 1

[0023] Under the protection of nitrogen, first add 81.6g of ammonia water with a concentration of about 25%, 54g of water, 87.08g of 2-oxazolidinone, and 0.69g of catalyst potassium carbonate into the reactor. Insulated reaction for 4 hours, the reaction was completed, post-treatment, the reaction product 2-hydroxyethylurea 101.2g, yield 97.3% based on 2-oxazolidinone.

Embodiment 2

[0025] Under the protection of nitrogen, first add 95.2g of ammonia water with a concentration of about 25%, 54g of water, 87.08g of 2-oxazolidinone, and 1.38g of catalyst potassium carbonate into the reactor. Insulated reaction for 4 hours, the reaction was completed, post-treatment, the reaction product 2-hydroxyethyl urea 102.0g, yield 98.1% based on 2-oxazolidinone.

Embodiment 3

[0027] Under the protection of nitrogen, first add 81.6g of ammonia water with a concentration of about 25%, 54g of water, 87.08g of 2-oxazolidinone, and 0.69g of catalyst potassium carbonate into the reactor. Insulated reaction for 6 hours, the reaction was completed, post-treatment, the reaction product 2-hydroxyethyl urea 101.9g, yield 97.9% based on 2-oxazolidinone.

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Abstract

The invention belongs to the technical field of fine chemical synthesis, and particularly relates to a preparation method of 2-hydroxyethyl urea, which comprises the following steps: using 2-oxazolidinone and ammonia water as reaction starting materials, sufficiently utilizing the chemical characteristic that the stability of amide functional groups is higher than that of ester functional groups to design a synthesis thought, and directly aminolyzing lactone by using ammonia water to prepare 2-hydroxyethyl urea. The method can solve the problems of low yield, low solid content of the actual 2-hydroxyethyl urea product and influence of the main byproduct 2-oxazolidinone on the product quality in the traditional ethanol amine method for preparing the 2-hydroxyethyl urea, and can provide a means for converting the byproduct 2-oxazolidinone into the product 2-hydroxyethyl urea for the ethanol amine method preparation process.

Description

technical field [0001] The invention belongs to the technical field of fine chemical synthesis, and in particular relates to a preparation method of 2-hydroxyethylurea. [0002] technical background [0003] 2-Hydroxyethylurea is a new type of high-performance cosmetic moisturizer. Compared with the traditional humectant glycerin, 2-hydroxyethylurea can not only retain moisture in a natural way, provide excellent moisturizing effect, improve the hand feeling characteristics of the formula, and significantly increase the cold resistance stability of the emulsified system, but also its use cost lower. In addition, the non-ionic properties and inherent stability of 2-hydroxyethyl urea also endow the product with a wider range of pH applications and can be compatible with most cosmetic raw materials. [0004] At present, high-end cosmetics manufacturers such as L'Oreal and Hanshu all use 2-hydroxyethylurea as a moisturizer, and nearly 10,000 products are used. It is a new type ...

Claims

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Application Information

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IPC IPC(8): C07C273/18C07C275/10
CPCC07C273/1836C07C275/10
Inventor 赵景瑞董杰张云雷陈曦杨正龙宋盛宗
Owner 禹城禹圳生物科技有限公司
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