Method for applying galactose combined with GALE (UDP-Galactose-4-epimerase) inhibitor to tumor prevention, treatment and rehabilitation

Abstract

The invention discloses a method for applying galactose combined with a GALE (UDP-Galactose-4-epimerase) inhibitor to tumor prevention, treatment and rehabilitation. Through the combined medication mode of galactose combined with the GALE inhibitor, the conversion of UDP-glucose to glycogen is reduced while the galactose supplements organisms with energy, ACEs synthesis is up-regulated, the activity of glycogen synthase kinase-3[beta] is regulated, the anti-apoptosis threshold level of tumor cells is finally reduced, the proliferation and metabolism of the tumor cells are interfered, the growth speed of tumors is reduced, the differentiation of the tumor cells is promoted, and the occurrence, growth and proliferation of the tumors are reduced.

Description

technical field [0001] The invention relates to the technical field of clinical tumor treatment, in particular to a method for applying galactose combined with GALE inhibitors in tumor prevention, treatment and rehabilitation. Background technique [0002] The incidence of tumor continues to increase, seriously endangering human health. The progress of basic and clinical science in the occurrence and development of tumors, especially the emergence of innovative achievements such as molecular targeting, immunology, and cell biotherapeutics, has led the treatment and prevention of tumors into a new stage. [0003] While targeted therapy, immunotherapy, and cell biotherapy have made continuous progress, tumor cells that have established an "ecological" support in the body have shown a high degree of heterogeneity and adaptability. Compared with normal cells, tumor cells There are stronger means to obtain new survivability through various reprogramming methods, so that the exis...

AI Technical Summary

Problems solved by technology

The research and development of anti-tumor metabolic drugs targeting key enzymes in the glycolytic pathway have also made some progress in recent years. However, most of the enzymes in the glycolytic pathway are necessary for normal cell metabolism, so Drugs targeting glycolytic enzymes may also have adverse effects on normal cell growth and regeneration

In addition, existing studies have also found that although some therapeutic drugs targeting metabolism have shown exciting effects in the early stage of treatment, the strong metabolic reprogramming ability of tumors has gradually offset the long-term efficacy of anti-tumor metabolic therapy

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