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Magnetic compatible optical brain function imaging method and device

An imaging method and brain function technology, applied in the field of biomedical imaging, can solve problems such as the difficulty in analyzing changes in capillary blood flow signals, and achieve the effect of high sensitivity and deep penetration depth

Active Publication Date: 2021-02-02
ZHEJIANG UNIV +1
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Problems solved by technology

MRI can perform large-scale imaging of the whole brain, but its resolution is only on the order of mm, which makes it difficult to analyze changes in neural signals and capillary blood flow signals in the cerebral cortex

Method used

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  • Magnetic compatible optical brain function imaging method and device
  • Magnetic compatible optical brain function imaging method and device
  • Magnetic compatible optical brain function imaging method and device

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Embodiment Construction

[0044] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, which form a part of this document. It should be noted that these descriptions and examples are illustrative only, and should not be construed as limiting the scope of the present invention. The protection scope of the present invention is defined by the appended claims, and any changes based on the claims of the present invention All are protection scope of the present invention.

[0045] In order to facilitate the understanding of the embodiments of the present invention, each operation is described as a plurality of discrete operations, however, the order of description does not represent the order in which the operations are performed.

[0046] In this description, the x-y-z three-dimensional coordinate representation based on the spatial direction is used for the sample measurement space. This description is provided merely to facilitate d...

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Abstract

The invention discloses a magnetic compatible optical brain function imaging method and device. The method is characterized in that an output scanning light beam of an optical coherence tomography system is transmitted to a magnetic resonance imaging device through a relay light path; brain tissue three-dimensional space optical scattered signal detection is conducted on the basis of an optical coherence technology, and meanwhile, magnetic resonance imaging detection is conducted through a magnetic resonance imaging device to obtain brain tissue magnetic resonance signals; event stimulation isconducted, and blood flow signals are extracted on the basis of rapid dynamic characteristics; and then, nerve tissue response signals of a non-blood-flow area are extracted on the basis of the dynamic characteristics of the event stimulation. According to the method, optical coherence imaging can be synchronously conducted under a nuclear magnetic resonance imaging condition, high-resolution nerve tissue and haemodynamics response signals are obtained, an OCT scanning light beam is transmitted to a sample position of an MRI machine area, an imaging harassing phenomenon does not exist, and label-free and high-resolution three-dimensional structure imaging and blood flow imaging can be realized.

Description

technical field [0001] The invention belongs to the field of biomedical imaging, relates to optical coherence tomography (Optical Coherence Tomography, OCT) and nuclear magnetic resonance imaging (Magnetic Resonance Imaging, MRI), in particular to a magnetically compatible optical brain function based on the principle of low coherence interference The imaging method and device can be used in the functional study of the cerebral cortex to study the activation of the biological cortical nerve blood flow under event stimulation. Background technique [0002] The brain is the core of the life movement of organisms and the focus of scientists' research. When the brain is exposed to external stimuli, it will produce changes in functional signals, which are closely related to biological functions. Therefore, it is of great significance to the pathological research of human diseases if we can accurately analyze the brain function signals--neural signal changes and blood flow signal...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/026A61B5/055
CPCA61B5/0066A61B5/0073A61B5/0263A61B5/0261A61B5/055A61B5/0035A61B5/0042
Inventor 李鹏姚霖张子艺
Owner ZHEJIANG UNIV
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