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Method and system for calculating tumor neoantigen load

An antigen and tumor technology, applied in biochemical equipment and methods, biostatistics, microbial measurement/testing, etc., can solve problems such as inconsistent thresholds

Pending Publication Date: 2021-02-02
深圳市新合生物医疗科技有限公司
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Problems solved by technology

Although these molecular indicators can assist in evaluating the efficacy of immune checkpoint inhibitors to a certain extent, there are still a large number of clinical cases where the efficacy is inconsistent with the existing molecular indicator thresholds

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  • Method and system for calculating tumor neoantigen load
  • Method and system for calculating tumor neoantigen load

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Embodiment Construction

[0052] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0053] The embodiment of the present invention provides a method for calculating tumor neoantigen load, such as figure 1 shown, including:

[0054] Step S1: Integrate the normal and tumor data of the sample, sequence the specific interval and detect the somatic mutation of the sample;

[0055] Step S2: Annotate and filter somatic mutations, and translate to obtain the patient's mutant polypeptide sequence;

[0056]Step S3: According to the normal protein group of the sample, filter the mutant polypeptide sequence to obtain a new polypeptide sequence;

[0057] Step S4: Perform human leukocyte antigen typing analysis according to the sample normal comparison data to...

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Abstract

The invention provides a method and system for calculating tumor neoantigen load. The method comprises the steps: S1, integrating normal and tumor data of a sample, sequencing a specific interval, anddetecting somatic mutation of the sample; S2, annotating and filtering the somatic mutation, and performing translating to obtain a mutant polypeptide sequence of the patient; S3, according to the normal proteome of the sample, filtering the mutant polypeptide sequence to obtain a new polypeptide sequence; and S4, performing human leukocyte antigen typing analysis according to the normal comparison data of the samples to obtain HLA genotypes of the samples; According to the method for calculating the tumor neoantigen load, weight scoring is performed on each predicted neoantigen, and high-quality and low-quality neoantigens can be distinguished by considering different dimension information such as mutation quality, mutation frequency, affinity and the like, so that a numerical value capable of better reflecting the real tumor neoantigen load of the sample is obtained.

Description

technical field [0001] The invention relates to the technical field of tumor immunotherapy, in particular to a method and system for calculating tumor neoantigen load. Background technique [0002] In recent years, the development of tumor immunotherapy has provided new means for the treatment of tumors. Among them, immune checkpoint inhibitors, which activate the immune system by inhibiting the inhibitory signals of the immune system, have achieved breakthrough efficacy in many solid tumors. Similar to tumor targeted therapy, immune checkpoint inhibitors need specific molecular indicators to predict the effect of treatment. Currently commonly used molecular indicators related to the efficacy of immune checkpoint inhibitors include the expression of PD-1 / PD-L1, microsatellite instability, and tumor mutation load. Although these molecular indicators can assist in evaluating the efficacy of immune checkpoint inhibitors to a certain extent, there are still a large number of c...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/10G16B40/00
CPCG16B30/10G16B40/00C12Q1/6869C12Q1/6881C12Q1/6886C12Q2600/156G16B20/20C12Q2535/122G16B20/30
Inventor 万季沈一鸣汪健潘有东王弈宋麒
Owner 深圳市新合生物医疗科技有限公司
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