Preparation method capable of improving yield of creatine nitrate

A technology of nitrate and creatine, which is applied in the field of creatine preparation, can solve the problems of insufficient reaction process and low yield of creatine nitrate, and achieve the effects of avoiding side reactions, high purity of creatine, and mild reaction process

Active Publication Date: 2021-02-05
湖南天成生化科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned reaction process is not t

Method used

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Examples

Experimental program
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Effect test

Example Embodiment

[0020]Example 1

[0021]A preparation method that can increase the yield of creatine nitrate, including the following steps:

[0022]S1. Mix 20kg of water, 20kg of activated carbon, and 1kg of phosphatidylcholine, add 40kg of creatine monohydrate and stir at room temperature for 10min, at a stirring speed of 1600r / min, reduce the speed to 100r / min, and continue stirring for 4h to obtain pretreated creatine;

[0023]S2. Stir the pretreated creatine at room temperature. During the stirring, slowly add 15kg of 58% nitric acid solution with a mass fraction of 58%. The nitric acid solution is added at a speed of 4kg / h. After the addition is complete, the ultrasonic treatment is continued for 2h, the ultrasonic power is 300W, and the ultrasonic frequency is 20kHz, get prefabricated material;

[0024]S3. Filter the prefabricated material to remove solids and slowly cool the remaining liquid. First, cool down from room temperature to 15°C at a rate of 1°C / min, let stand for 1 hour, and continue to cool...

Example Embodiment

[0025]Example 2

[0026]A preparation method that can increase the yield of creatine nitrate, including the following steps:

[0027]S1. Mix 40kg of water, 10kg of activated carbon, and 2kg of phosphatidylcholine, add 20kg of creatine monohydrate and stir at room temperature for 20 minutes, at a stirring speed of 1200r / min, reduce the speed to 400r / min, and continue stirring for 2h to obtain pretreated creatine;

[0028]S2. Stir the pretreated creatine at room temperature. During the stirring, slowly add 20kg of 50% nitric acid solution with a mass fraction of 50%. The nitric acid solution is added at a speed of 10kg / h. After the addition is complete, the ultrasonic treatment is continued for 1h, the ultrasonic power is 400W, and the ultrasonic frequency is 15kHz, get prefabricated material;

[0029]S3. Filter the prefabricated material to remove solids and slowly lower the temperature of the remaining liquid. First, cool down from room temperature to 10°C at a rate of 2°C / min, let stand for 2 ...

Example Embodiment

[0030]Example 3

[0031]A preparation method that can increase the yield of creatine nitrate, including the following steps:

[0032]S1. Mix 25kg of water, 17kg of activated carbon, and 1.3kg of phosphatidylcholine, add 35kg of creatine monohydrate and stir at room temperature for 12 minutes, at a stirring speed of 1500r / min, reduce the speed to 200r / min, and continue stirring for 3.5h to obtain pretreated muscle acid;

[0033]S2. Stir the pretreated creatine at room temperature. During the stirring, slowly add 16kg of 56% nitric acid solution with a mass fraction of 4kg / h. After the addition is complete, continue ultrasonic treatment for 1.7h, the ultrasonic power is 320W, the ultrasonic frequency It is 19kHz to get the preform;

[0034]S3. Filter the preform to remove solids and slowly cool the remaining liquid. First, cool down from room temperature to 13°C at a rate of 1.3°C / min, let stand for 1.3 hours, and continue to cool to 2°C at a rate of 0.16°C / min , Stand for 3.5h, vacuum dry at 42℃...

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Abstract

The invention discloses a preparation method capable of improving the yield of creatine nitrate, which comprises the following steps of mixing water, activated carbon and phosphatidylcholine, adding creatine monohydrate, stirring at normal temperature for 10-20 minutes at the stirring speed of 1,200-1,600 r/min, reducing the speed to 100-400 r/min, and continuing stirring for 2-4 hours to obtain pretreated creatine, stirring the pretreated creatine at normal temperature, slowly adding a nitric acid solution in the stirring process, and continuously carrying out ultrasonic treatment at the ultrasonic power of 300-400W and the ultrasonic frequency of 15-20kHz for 1-2 hours after the nitric acid solution is completely added, so as to obtain a prefabricated material, filtering the prefabricated material, removing solids, slowly cooling the residual liquid, firstly cooling from room temperature to 10-15 DEG C at a speed of 1-2 DEG C/min, standing for 1-2 hours, continuously cooling to 1-5 DEG C at a speed of 0.1-0.2 DEG C/min, standing for 2-4 hours, carrying out vacuum drying, and cooling to obtain the creatine nitrate.

Description

technical field [0001] The invention relates to the technical field of creatine preparation, in particular to a preparation method capable of increasing the yield of creatine nitrate. Background technique [0002] Creatine is an important muscle supplement nutrient for the body to improve and enhance muscle performance and strength. At the same time, creatine also has the effect of treating heart disease, enhancing cognitive function and treating asthma. The market demand for it is increasing. However, creatine is not easily soluble in water, which seriously affects oral administration and absorption. Therefore, various inorganic acid salts, organic acid salts and esters of creatine have been prepared. Studies have found that creatine nitrate has good water solubility, and it can also improve vasodilation and blood circulation after oral administration. [0003] At present, the preparation method of related creatine nitrate has been reported in China, such as CN 104693073...

Claims

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Application Information

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IPC IPC(8): C07C277/08C07C279/14
CPCC07C277/08C07C279/14
Inventor 苏迎春
Owner 湖南天成生化科技有限公司
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