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Preparation method capable of improving yield of creatine nitrate

A technology of nitrate and creatine, which is applied in the field of creatine preparation, can solve the problems of insufficient reaction process and low yield of creatine nitrate, and achieve the effects of avoiding side reactions, high purity of creatine, and mild reaction process

Active Publication Date: 2021-02-05
湖南天成生化科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned reaction process is not thorough enough, creatine nitrate yield is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method capable of improving the yield of creatine nitrate, comprising the steps of:

[0022] S1. Mix 20kg of water, 20kg of activated carbon, and 1kg of phosphatidylcholine, add 40kg of creatine monohydrate and stir at room temperature for 10 minutes at a stirring speed of 1600r / min, reduce the speed to 100r / min, and continue stirring for 4 hours to obtain pretreated creatine;

[0023] S2. Stir the pretreated creatine at room temperature. During the stirring process, slowly add 15kg of nitric acid solution with a mass fraction of 58%. The nitric acid solution is added at a rate of 4kg / h. After the addition is complete, continue ultrasonic treatment for 2h. The ultrasonic power is 300W, and the ultrasonic frequency is 20kHz, get the prefabricated material;

[0024] S3. Filter the prefabricated material to remove the solid matter, and slowly cool down the remaining liquid, first cooling down from room temperature to 15°C at a rate of 1°C / min, standing for 1 ...

Embodiment 2

[0026] A preparation method capable of improving the yield of creatine nitrate, comprising the steps of:

[0027] S1. Mix 40kg of water, 10kg of activated carbon, and 2kg of phosphatidylcholine, add 20kg of creatine monohydrate and stir at room temperature for 20 minutes at a stirring speed of 1200r / min, reduce the speed to 400r / min, and continue stirring for 2 hours to obtain pretreated creatine;

[0028] S2. Stir the pretreated creatine at room temperature. Slowly add 20kg of nitric acid solution with a mass fraction of 50% during the stirring process. The nitric acid solution is added at a speed of 10kg / h. After the addition is complete, continue ultrasonic treatment for 1h. The ultrasonic power is 400W, and the ultrasonic frequency is 15kHz, get the prefabricated material;

[0029] S3. Filter the prefabricated material to remove the solid matter, slowly cool down the remaining liquid, firstly cool down from room temperature to 10°C at a rate of 2°C / min, let it stand for 2 ...

Embodiment 3

[0031] A preparation method capable of improving the yield of creatine nitrate, comprising the steps of:

[0032] S1. Mix 25kg of water, 17kg of activated carbon, and 1.3kg of phosphatidylcholine, add 35kg of creatine monohydrate and stir at room temperature for 12min at a stirring speed of 1500r / min, reduce the speed to 200r / min, and continue stirring for 3.5h to obtain pretreated muscle acid;

[0033] S2. Stir the pretreated creatine at room temperature. During the stirring process, slowly add 16kg of nitric acid solution with a mass fraction of 56%. The nitric acid solution is added at a rate of 4kg / h. After the addition is complete, continue ultrasonic treatment for 1.7h. It is 19kHz, and the prefabricated material is obtained;

[0034] S3. Filter the prefabricated material to remove the solid matter, slowly cool down the remaining liquid, firstly cool down from room temperature to 13°C at a speed of 1.3°C / min, let stand for 1.3h, and continue to cool down to 2°C at a spe...

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Abstract

The invention discloses a preparation method capable of improving the yield of creatine nitrate, which comprises the following steps of mixing water, activated carbon and phosphatidylcholine, adding creatine monohydrate, stirring at normal temperature for 10-20 minutes at the stirring speed of 1,200-1,600 r / min, reducing the speed to 100-400 r / min, and continuing stirring for 2-4 hours to obtain pretreated creatine, stirring the pretreated creatine at normal temperature, slowly adding a nitric acid solution in the stirring process, and continuously carrying out ultrasonic treatment at the ultrasonic power of 300-400W and the ultrasonic frequency of 15-20kHz for 1-2 hours after the nitric acid solution is completely added, so as to obtain a prefabricated material, filtering the prefabricated material, removing solids, slowly cooling the residual liquid, firstly cooling from room temperature to 10-15 DEG C at a speed of 1-2 DEG C / min, standing for 1-2 hours, continuously cooling to 1-5 DEG C at a speed of 0.1-0.2 DEG C / min, standing for 2-4 hours, carrying out vacuum drying, and cooling to obtain the creatine nitrate.

Description

technical field [0001] The invention relates to the technical field of creatine preparation, in particular to a preparation method capable of increasing the yield of creatine nitrate. Background technique [0002] Creatine is an important muscle supplement nutrient for the body to improve and enhance muscle performance and strength. At the same time, creatine also has the effect of treating heart disease, enhancing cognitive function and treating asthma. The market demand for it is increasing. However, creatine is not easily soluble in water, which seriously affects oral administration and absorption. Therefore, various inorganic acid salts, organic acid salts and esters of creatine have been prepared. Studies have found that creatine nitrate has good water solubility, and it can also improve vasodilation and blood circulation after oral administration. [0003] At present, the preparation method of related creatine nitrate has been reported in China, such as CN 104693073...

Claims

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Application Information

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IPC IPC(8): C07C277/08C07C279/14
CPCC07C277/08C07C279/14
Inventor 苏迎春
Owner 湖南天成生化科技有限公司
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