Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for predicting muscle strength decrease and screening sarcopenia based on serum creatinine and cystatin C

A technology of serum creatinine and cystatin, applied in the field of sarcopenia detection, can solve the problem of not being able to accurately identify the skeletal muscle mass of the elderly in the community, and achieve the effect of reducing the size of the population, saving manpower and cost

Pending Publication Date: 2021-02-09
WEST CHINA HOSPITAL SICHUAN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the study found that the sarcopenia index does not accurately identify whether community-dwelling older adults have reduced skeletal muscle mass or sarcopenia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for predicting muscle strength decrease and screening sarcopenia based on serum creatinine and cystatin C
  • Method for predicting muscle strength decrease and screening sarcopenia based on serum creatinine and cystatin C

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] This example is based on the population. Among different populations, the grip strength of the 40-year-old (31-40 years old) population is the highest; therefore, we invite community adults aged ≥ 40 years old to participate in this study. The exclusion criteria were impaired renal function (estimated glomerular filtration rate 2 ), any injury or disease of the hand and arm that may affect grip strength measurements, and any type of cancer. Clinical information and blood samples were collected from the subjects, and anthropometric measurements and grip strength tests were performed.

[0037] When performing grip strength measurements, grip strength was measured using a digital dynamometer, which has an adjustable grip strength measurement between 0.1-100.0kg in increments of 0.1kg. The measurement program adopts the recommendations put forward in the "China National Physical Fitness Measurement Standards". First, distribute the instructions for using the dynamometer to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for predicting muscle strength decrease and screening sarcopenia based on serum creatinine and cystatin C, and belongs to the field of sarcopenia detection. The methodcomprises the following steps: obtaining serum creatinine and cystatin C; taking the ratio of serum creatinine to cystatin C as a marker for screening grip strength reduction; constructing and training a relation model between the ratio of serum creatinine to cystatin C and grip strength; determining appropriate diagnosis critical values of ratios of serum creatinine to cystatin C of users of different genders based on the relation model; determining a predicted value in grip reduction of the corresponding gender according to the appropriate diagnosis critical values of the users of differentgenders; predicting muscle strength reduction according to the prediction value. According to the invention, the relationship between the ratio of serum creatinine to cystatin C and the grip strengthcan be determined, and the condition that the grip strength in the crowd is reduced is identified according to the calculated ratio of serum creatinine to cystatin C, so that accurate prediction is provided for further detecting sarcopenia, and the scale of the crowd needing to screen sarcopenia is greatly reduced.

Description

technical field [0001] The invention relates to the field of detection of sarcopenia, in particular to a method for predicting muscle strength decline and screening for sarcopenia based on serum creatinine and cystatin C. Background technique [0002] Sarcopenia is an age-related skeletal muscle disorder characterized by atrophy and decreased function of skeletal muscles. The worldwide prevalence of the disease, especially among the elderly, has become an important public health problem. The most widely used criteria for the diagnosis of sarcopenia are those of the European Working Group on Sarcopenia in Geriatrics (EWGSOP). The latest EWGSOP recommendations (EWGSOP2) state that the diagnosis of sarcopenia requires first measurement of muscle strength (usually grip strength using a hand dynamometer), followed by dual-energy X-ray (DXA), computed tomography ( CT), bioelectrical impedance (BIA) and magnetic resonance imaging (MRI) to assess muscle mass and then comprehensive...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G06N3/04G06N3/08G06F17/18G01N33/52G01N33/68G01N33/539G01N33/72A61B5/22
CPCG06N3/08G06F17/18G01N33/52G01N33/6827G01N33/539G01N33/721A61B5/225G01N2333/4737G06N3/045
Inventor 杨茗李蕊岑谭玲玲蒋佼佼吴锦晖
Owner WEST CHINA HOSPITAL SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com