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Fish protein hydrolysate powder and composition comprising said powder for use as medicament

A technology of fish protein hydrolyzate and composition, which is applied in the field of preventing or treating oxidative damage of the gastrointestinal tract and central nervous system, and protecting the gastrointestinal tract and central nervous system from oxidative damage, and can solve the problem of increased toxicity of metabolites and increased oxidation Metabolite susceptibility, chemotoxic necrotizing colitis, etc.

Pending Publication Date: 2021-02-12
HOFSETH BIOCARE AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further mucosal metabolism can lead to increased metabolite toxicity, increased oral and gastrointestinal susceptibility to oxidative metabolites, chemotoxicity, and potential necrotizing colitis

Method used

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  • Fish protein hydrolysate powder and composition comprising said powder for use as medicament
  • Fish protein hydrolysate powder and composition comprising said powder for use as medicament
  • Fish protein hydrolysate powder and composition comprising said powder for use as medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060]Example 1-Preparation of fish hydrolysate powder with biological activity according to the present invention

[0061]Salmon protein hydrolysate powder is produced by enzymatically hydrolyzing the head and backbone of sliced ​​salmon (Atlantic salmon). 1000 grams of ground head and spine were added to 1000 ml of water, and the mixture was heated to 50°C. 10 g of endopeptidase-pepsin was added and stirred for 30 minutes. 10 g of exopeptidase-carboxypeptidase was further added thereto and stirred for 15 minutes. 5 g of flavor protease (R) (protease derived from Aspergillus oryzae) was added thereto, and the mixture was stirred for 10 minutes. The entire mixture was then heated to 85°C, kept at that temperature for 15 minutes and filtered. The hydrolysate fraction is concentrated to 30% dry matter in a conventional evaporator, and spray-dried to produce the fish protein hydrolysate powder of the present invention, which is a light yellow free-flowing powder with the biological charac...

Embodiment 2

[0062]Example 2-Preparation of fish hydrolysate powder without biological effect

[0063]Except that the exopeptidase used was an aminopeptidase instead of a carboxypeptidase, salmon protein hydrolysate powder was produced as described in Example 1 above. A powder with no biological efficacy was obtained (data not shown).

[0064]Details: Salmon protein hydrolysate powder is produced by enzymatic hydrolysis of sliced ​​salmon (Atlantic salmon) head and spine. 1000 grams of ground head and spine were added to 1000 ml of water, and the mixture was heated to 50°C. 10 g of endopeptidase-pepsin was added and stirred for 30 minutes. 10 g of exopeptidase-aminopeptidase was further added thereto and stirred for 15 minutes. 5 g of flavor protease (R) was further added thereto, and the mixture was stirred for 10 minutes. The entire mixture was then heated to 85°C, kept at that temperature for 15 minutes and filtered. The water layer is concentrated to 30% dry matter in a conventional evaporator and...

Embodiment 3

[0065]Example 3-Preparation of fish hydrolysate powder without biological effect

[0066]Except for adding exopeptidase (carboxypeptidase) before the endopeptidase, salmon protein hydrolysate powder was produced as described in Example 1 above. A powder with no biological efficacy was obtained (data not shown).

[0067]Details: Salmon protein hydrolysate powder is produced by enzymatic hydrolysis of sliced ​​salmon (Atlantic salmon) head and spine. 1000 grams of ground head and spine were added to 1000 ml of water, and the mixture was heated to 50°C. Add 10 grams of exopeptidase-carboxypeptidase and stir for 30 minutes. 10 g of endopeptidase-pepsin was further added and stirred for 15 minutes. 5 g of flavor protease (R) was further added thereto, and the mixture was stirred for 10 minutes. The entire mixture was then heated to 85°C, kept at that temperature for 15 minutes and filtered. The water layer is concentrated to 30% dry matter in a conventional evaporator and spray dried to produc...

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Abstract

An enzymatic hydrolysisprocess for producing a fishprotein hydrolysate powder is provided. Furtherprovidedisuse of the fishprotein hydrolysate powder obtained and a composition comprising said powderas a medicament, preferably for the prophylaxis or treatment of oxidative damage of the gastro-intestinal and central nervous system.

Description

Technical field[0001]The present invention relates to an enzymatic hydrolysis method for producing fish protein hydrolysate powder. The present invention further relates to the use of the fish protein hydrolysate powder obtained by the method and the composition containing the powder as a medicine, preferably for preventing or treating oxidative damage of the gastrointestinal tract and central nervous system.[0002]The present invention relates to fish protein hydrolysate and its constituent peptides, which aim to regulate the function of human oxidative protection genes, which provide protection against oxidative damage in various organs and tissues. More specifically, the present invention relates to one or more peptide compounds having oxidative protection gene regulating activity incorporated into oral preparations. The present invention also relates to a method for protecting the gastrointestinal tract and central nervous system from oxidative damage. The method comprises oral i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A23J1/04A61K38/01A61P1/00
CPCA61K35/60A23J1/04A61K38/012A61P1/00A23J3/08A23J3/341A61P39/06
Inventor B·P·弗拉姆罗泽
Owner HOFSETH BIOCARE AS