Orthopaedic implantation instrument with osteogenesis promoting coating on surface and preparation method
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A technology that promotes bone and equipment. It is used in coatings, medical science, prostheses, etc. It can solve the problems of surgical failure, easy loosening, and lack of osseointegration performance. It is beneficial to adhesion, promotes cell proliferation, and improves Effects of insufficient osseointegration
Pending Publication Date: 2021-02-26
SHANGHAI CITY JIADING DISTRICT CENT HOSPITAL
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However, titanium implants with smooth surfaces are not biologically active, so they do not have good osseointegration properties, and they tend to loosen after implantation in patients, resulting in surgical failure
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[0032] 3) Preparation of salidroside solution: mixing salidroside with PBS buffer solution to prepare a solution, and dissolving under stirring conditions to obtain a salidroside solution. Then add the salidroside solution to the surface of the material containing the PDA film layer, avoid light reaction, and complete the loading preparation of salidroside on the surface of the implanted device;
[0033] 4) Rinse the material with deionized water and dry it naturally.
[0034] Preferably, in the above step 1, the orthopedic implant device may be titanium implant device, polyetheretherketone (PEEK) implant material, alloy, polymer material and inorganic ceramic material.
[0035] Preferably, in the above step 1, the micro-nano structure can obtain a three-dimensional porous structure by performing micro-arc oxidation treatment on the titanium implant device, and the micro-nano structure includes nanotubes, nanopores, and micron or nanometer-sized pits, pores, Reticular, filame...
Embodiment 1
[0046] The process of preparing polydopamine coating containing salidroside on the surface of medical pure titanium is as follows: figure 1 As shown, the specific steps are as follows:
[0047] (1) Base material pretreatment: Cut medical pure titanium to obtain a pure titanium test piece with a length and width of 10 mm and a thickness of 1 mm, and then polish it step by step with 240 to 1500 mesh sandpaper until the surface is smooth and No trace. Ultrasonic cleaning in absolute ethanol for 5 min, followed by rinsing with distilled water three times. Blot the surface moisture with filter paper, air-dry naturally, and store in a desiccator.
[0048] (2) Micro-arc oxidation treatment of pure titanium: soak the pure titanium test piece in the electrolyte composed of sodium hexametaphosphate 5g / L, sodium silicate 12g / L, sodium hydroxide 3g / L, glycerin 2g / L, and carry out Micro-arc oxidation treatment. Micro-arc oxidation equipment - 70kW bipolar pulse micro-arc oxidation powe...
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Abstract
The invention provides an orthopaedic implantation instrument with an osteogenesis promoting coating on the surface and further discloses a preparation method of the orthopaedic implantation instrument. A polydopamine coating is arranged on the surface of a smooth orthopaedic implantation instrument base body or an orthopaedic implantation instrument base body with a micro-nano structure, and salidroside is fixed on the surface of the polydopamine coating to form the osteogenesis promoting coating. The preparation method of the orthopaedic implantation instrument comprises the following steps:1) pretreating the orthopaedic implantation instrument base body to obtain a smooth or micro-nano structure surface appearance on the surface; (2) after the orthopaedic implantation instrument base body is pretreated, adding the orthopaedic implantation instrument into a dopamine solution to react for a period of time to form the polydopamine coating on the surface of the orthopaedic implantationinstrument, then putting the orthopaedic implantation instrument into a solution containing the salidroside, and fixing the salidroside on the surface of the orthopaedic implantation instrument by utilizing the excellent bonding performance of the polydopamine coating on the surface of the orthopaedic implantation instrument; and 3) rinsing the material with deionized water, and naturally dryingthe rinsed material.
Description
technical field [0001] The invention belongs to the field of surface modification and drug slow release of medical devices, and in particular relates to an orthopedic implant device with a bone-promoting coating on the surface. [0002] The present invention also relates to a method for preparing the above-mentioned orthopedic implant device. Background technique [0003] Medical implants are very important for clinical bone defect repair. The demand for implants has increased dramatically over the past 5 years (the number of hip revisions has increased by 26% and is expected to reach 137% by 2030). Titanium (Ti) is a high-gloss transition metal with low density, high strength, high fracture toughness, biocompatibility and extremely strong corrosion resistance. Titanium implants have good mechanical properties, corrosion resistance and biocompatibility, and are widely used. However, titanium implants with smooth surfaces have no biological activity, so they do not have go...
Claims
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