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Pharmaceutical composition and eye drops for preventing and controlling myopia development and preparation method and application of eye drops

A technology of eye drops and compositions, applied in the field of myopia drugs, can solve problems such as poor stability, achieve good application prospects, prevent and delay the effect of juvenile myopia

Pending Publication Date: 2021-03-02
山东中观明视医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the course of clinical research, it was found that high concentration of atropine drugs will be accompanied by many adverse reactions and side effects, while low concentration of atropine solution is easy to oxidize, so the stability is not good

Method used

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  • Pharmaceutical composition and eye drops for preventing and controlling myopia development and preparation method and application of eye drops
  • Pharmaceutical composition and eye drops for preventing and controlling myopia development and preparation method and application of eye drops
  • Pharmaceutical composition and eye drops for preventing and controlling myopia development and preparation method and application of eye drops

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preparation example Construction

[0048]In the third aspect, the present invention provides a method for preparing the eye drops, which includes the following steps:

[0049]After the stabilizer, thickener, acid-base regulator, bacteriostatic agent and osmotic pressure buffer are completely dissolved in water, add atropine drugs to dissolve evenly, and get it after filtration;

[0050]Or, after the atropine drugs are completely dissolved in water, add stabilizers, thickeners, acid-base regulators, bacteriostatic agents, and osmotic pressure buffer solutions, mix them evenly, and filter the solution.

[0051]In some embodiments, the pore size of the filter is 0.22 μm or 0.2 μm.

Embodiment 1

[0053]A kind of eye drops that can prevent and treat the development of myopia, including atropine sulfate, isotonic regulator and diluent, used every night, and the ratio of each component is:

[0054]

[0055]Preparation method: Stir the prescription amount of sodium chloride with 90% water for injection or distilled water until the dissolution is complete, add the prescription amount of atropine drugs and stir to dissolve completely, filter through a 0.22μm (or 0.2μm) filter, under aseptic conditions Filling, ready to go.

Embodiment 2

[0057]A kind of eye drops that can prevent and treat the development of myopia, including atropine sulfate, bacteriostatic agent, isotonic regulator and diluent, used every night, and the ratio of each component is:

[0058]

[0059]Preparation method: Use appropriate amount of water for injection or distilled water to stir the prescription amount of bacteriostatic agent until dissolution is complete, add prescription amount of atropine and stir to dissolve completely, filter through 0.22μm (or 0.2μm) filter, and irrigate under sterile conditions. Install and get it.

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Abstract

The invention discloses a pharmaceutical composition for preventing and controlling myopia development, eye drops, and a preparation method and application thereof, and the eye drops are composed of the following components, by w / v, 0.001%-2% of atropine drugs, 0%-2% of a thickening agent, an acid-base regulator, an osmotic pressure buffer agent, 0%-2.2% of a stabilizer, 0%-0.05% of a bacteriostatic agent, and the balance of water, the pH value of the pharmaceutical composition is 3.0-8.5, and the osmotic pressure of the pharmaceutical composition is 260-380m <0> sm / L, wherein the stabilizer is selected from one or more of sodium pyrosulfite, sodium hydrogen sulfite, sodium sulfite, sodium thiosulfate, thiourea, vitamin C, cysteine or hydrochloride thereof, citric acid and tartaric acid. The eye drops can effectively prevent and delay juvenile myopia, and have a good application prospect.

Description

Technical field[0001]The invention belongs to the technical field of myopia medicines, and specifically relates to a pharmaceutical composition, eye drops for preventing and controlling the development of myopia, and a preparation method and application thereof.Background technique[0002]Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or any form of suggestion that the information constitutes the prior art known to those of ordinary skill in the art.[0003]At present, myopia has become the most common disease among young people, and it is a major public health problem faced by countries all over the world. In recent years, due to the pressure of study and the influence of electronic products, this situation is particularly severe in our country, especially among our young people. According to statistics, our country's young people suffer fro...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/46A61K45/00A61K47/02A61K47/12A61K47/18A61K47/20A61K47/22A61P27/10
CPCA61K9/08A61K9/0048A61K31/46A61K45/00A61K47/22A61K47/02A61K47/183A61K47/12A61K47/20A61P27/10
Inventor 权春满
Owner 山东中观明视医药科技有限公司
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