Multi-task high-order SNP upper detection method and system, storage medium and equipment

A detection method and multi-task technology, applied in the fields of proteomics, instrumentation, genomics, etc., can solve the problems of high computational complexity of detection methods, insufficient success rate of detection algorithms, and inaccurate search results, and achieve enhanced global search. ability, improve global search ability, and solve the effect of low identification accuracy
CN112447263APending Publication Date: 2021-03-05XIAN UNIV OF POSTS & TELECOMM
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAN UNIV OF POSTS & TELECOMM
Publication Date
2021-03-05

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of single nucleotide polymorphism upper detection, and discloses a multi-task high-order SNP upper detection method and a system, a storage medium and equipment. The multi-task high-order SNP upper detection method comprises the following steps: reading PED and MAP format data from a VCF file by using Plink software, converting a bit binary format file,and arranging the bit binary format file into a sample matrix; setting search algorithm parameters according to the sizes of the SNP sites and the sample size in the data; reading in SNP sample data,and preparing first-stage search; carrying out high-order SNP upper combination detection by utilizing a multi-task and multi-harmony memory bank harmony search (HS) algorithm. According to the multi-task harmony search detection method provided by the invention, a plurality of harmony memory banks are adopted, SNP combinations of different orders are respectively stored, and a multi-task technology is applied, so that high-order SNP upper detection of a plurality of different orders can be carried out at the same time, mutual learning among individuals in a population is promoted, the diversity of the population is enhanced, and the global search capability is further improved.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of single nucleotide polymorphism epistasis detection, and in particular relates to a multi-task high-order SNP epistasis detection method, system, storage medium and equipment. Background technique

[0002] At present: SNP (Single Nucleotide Polymorphism, SNP) refers to the polymorphism caused by the variation of a single base site at the genome level, which may be a single base conversion (transition) or transversion (transversion), It may also be due to insertion or deletion of bases. A base pair C-G in sequence 1 is expressed as A-T in sequence 2, and this site is called a SNP site. In the whole human genome, there are more than 3 million such SNP sites. Under normal circumstances, most of the SNPs will not pose a threat to human health, but some SNP variation sites are closely related to human health. Epistatic effect: Indicates the interaction between a gene or SNP, traditionally defined as an allele...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More