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Artificially synthesized antibacterial peptide and application thereof

一种人工合成、抗菌肽的技术，应用在阳离子抗菌肽、应用、抗细菌药等方向，能够解决尚未见到系统设计方法介绍及应用等问题，达到解决成本高的效果

Active Publication Date: 2021-03-12
ZUNYI MEDICAL UNIV ZHUHAI CAMPUS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no relevant reports on the introduction and application of effective and systematic design methods

Method used

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  • Artificially synthesized antibacterial peptide and application thereof
  • Artificially synthesized antibacterial peptide and application thereof
  • Artificially synthesized antibacterial peptide and application thereof

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Experimental program
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Embodiment Construction

[0042] In order to describe in detail the technical content, structural features, achieved objectives and effects of the present invention, the following will be described in detail in conjunction with the embodiments.

[0043] Embodiment 1 of the present invention is: a method for artificially synthesizing an antimicrobial peptide, comprising the following steps: based on the antimicrobial peptide LL37 sequence (as shown in Seq ID. The basic skeleton sequence SETRPVLNRLFDKIRQVIRKFEKGIKEKSKRFFDGLL was obtained, and the sequence was named SE37 (as shown in Seq ID. No. 2).

[0044] Amino acid substitution or removal of some amino acid residues with SE37 was used to obtain a series of mutants, as follows:

[0045] (1) Based on SE37, remove some amino acid residues at the back end to obtain SE30 (as shown in Seq ID.No.3), and predict its possibility of becoming an antimicrobial peptide through software SVM, Random Forest, Artificial Neural Network and Discriminant Analysis theory ...

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PUM

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Abstract

The invention discloses an artificially synthesized antibacterial peptide an and application thereof. The sequence of the antibacterial peptide is shown as Seq No. ID 7. The invention further providesa design method of the novel antibacterial peptide, a method combining bioinformatics theoretical design and test evaluation is adopted, the antibacterial peptide with a novel sequence can be rapidlyand effectively obtained, and according to the design method of the novel antibacterial peptide, the method can be well applied to modification of natural antibacterial peptides and design of artificial antibacterial peptides.

Description

[0001] This case is a divisional application based on the patent application with the application number 2019104871822 and the application date on June 5, 2019, entitled "An artificially synthesized antimicrobial peptide and its design method and application". technical field [0002] The invention relates to the field of biotechnology, in particular to an artificially synthesized antibacterial peptide and its application. Background technique [0003] Antibiotics, as an important class of anti-infective drugs, have saved countless lives since their application. However, with the long-term high-dose use of antibiotics in clinical and animal husbandry, multidrug-resistant bacteria have begun to spread under the joint action of factors such as the selection pressure of antibiotics, the horizontal spread of drug-resistant genes, and the spread of drug-resistant clones. [1] . Clinically common drug-resistant bacteria include multidrug-resistant acinetobacter baumannii (MDRAB), ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47A61K38/17A61P31/04A61K8/64A61Q19/00A23L3/3526A23K20/147A23K20/195
CPCA23K20/147A23L3/3526A61P31/04A61K38/00A23V2002/00C07K14/4723A61K8/64A61Q19/00A23K20/195A61K2800/524A23V2200/10A23V2250/55
Inventor 杨愈丰王燕夏嫱谢明峰许佳伟李均刘振勇彭莉萍
Owner ZUNYI MEDICAL UNIV ZHUHAI CAMPUS