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Preparation method of calcium fumarate

A technology of calcium fumarate and fumaric acid, which is applied in the preparation of carboxylate, carboxylate, and organic compounds, can solve problems such as complex processes, and achieve cheap and easy-to-obtain raw materials, simple and convenient operations, and fast The effect of efficient preparation

Pending Publication Date: 2021-03-23
河南瑞贝佳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its process is more complicated

Method used

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preparation example Construction

[0014] The embodiment of the present invention provides a kind of preparation method of calcium fumarate, it comprises:

[0015] S1. Fumaric acid and sodium carbonate are mixed and dissolved to obtain a mixed solution;

[0016] S2. mixing the mixed solution with the calcium chloride solution at high temperature to obtain a reaction solution;

[0017] S3. Filter the reaction solution, collect the filter residue and dry it.

[0018] In this method, by mixing fumaric acid and sodium carbonate to generate a soluble intermediate product, and then reacting with calcium chloride, the product and reaction efficiency of calcium fumarate can be effectively improved.

[0019] Further, the mass ratio of fumaric acid to sodium carbonate is 1:0.94~0.98. The concentration of fumaric acid is 0.25~0.35g / mL. Within the above ratio range, the reaction efficiency of fumaric acid and sodium carbonate is better, and the desired intermediate product can be obtained quickly and efficiently. Alter...

Embodiment 1

[0025] The present embodiment provides a kind of preparation method of calcium fumarate, it comprises:

[0026] S1. Measure 500 ml of distilled water into a beaker, add 155 g of fumaric acid, stir to dissolve, then add 147 g of sodium carbonate, stir until clear and transparent, filter for about 1 h, and obtain a mixed solution;

[0027] S2. measure the distilled water of 300 ml and pour into the beaker, add the calcium chloride of 200 g, stir and dissolve, obtain calcium chloride solution;

[0028] S3. Mix the calcium chloride solution with the mixed solution, and react at 80° C. for 2 h to obtain a reaction solution;

[0029] S4. Filter the reaction solution, collect the filter residue, and dry at 120°C for 2 h to obtain the calcium fumarate product (white solid, yield 86.4%, calcium content 26.8%).

Embodiment 2

[0031] The present embodiment provides a kind of preparation method of calcium fumarate, it comprises:

[0032] S1. Measure 300 ml of distilled water into a beaker, add 100 g of fumaric acid, stir to dissolve, then add 98 g of sodium carbonate, stir until clear and transparent, filter for about 1 h, and obtain a mixed solution;

[0033] S2. measure the distilled water of 300 ml and pour into the beaker, add the calcium chloride of 133 g, stir and dissolve, obtain calcium chloride solution;

[0034] S3. Mix the calcium chloride solution with the mixed solution, and react at 85° C. for 3 h to obtain a reaction solution;

[0035] S4. Filter the reaction solution, collect the filter residue, and dry at 150°C for 0.5 h to obtain the calcium fumarate product (white solid, yield 81.7%, calcium content 23.5%).

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Abstract

The invention provides a preparation method of calcium fumarate, belonging to the technical field of compound preparation. The preparation method comprises the following steps: mixing fumaric acid with sodium carbonate, and then conducting reacting with calcium chloride at high temperature. The preparation method has the advantages of usage of cheap and easily available raw materials, simple and convenient operation, low requirements on equipment, and realization of rapid and efficient preparation of calcium fumarate; single batch feeding can reach a scale of 500 g or above, and high yield canbe obtained; and thus, the preparation method is suitable for large-scale production, and has a good industrialization prospect. Moreover, a produced calcium fumarate product is high in purity, the quality of the product meets national standards in China, the calcium content of the product reaches 23.0%-27.0%, and the calcium fumarate product can be applied as a calcium supplement to food addition.

Description

technical field [0001] The invention relates to the technical field of compound preparation, in particular to a preparation method of calcium fumarate. Background technique [0002] The molecular formula of calcium fumarate is C 8 h 6 CaO 8 , white particles, insoluble in water. Calcium is the most abundant mineral in the human body. It participates in the entire life process of the human body and is the foundation of human life. Calcium is involved in almost all life phenomena and various physiological processes, such as the emotions of the brain, immunity of the body, detoxification ability of the liver, hormone secretion of endocrine glands, etc. Many foods eaten in daily life are rich in calcium, such as dairy products, yuba, kelp, soybeans, black fungus, fish and shrimp, etc. Although these foods are rich in calcium, the absorption of calcium by the human body may not always meet the requirements of the human body, so many people need proper calcium supplementation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C57/15A23L33/16
CPCC07C51/412A23L33/16A23V2002/00C07C57/15A23V2250/1578
Inventor 梅志恒李培杰陈礼宝李秀康
Owner 河南瑞贝佳生物科技有限公司