The invention also discloses application of PARP inhibitor PJ34 in preparation of anti-fish rhabdovirus products

A rhabdovirus and inhibitor technology, applied in the field of aquaculture, can solve the problems of aquaculture environment residues, endangering human safety, etc.

Active Publication Date: 2021-03-30
HEILONGJIANG RIVER FISHERY RES INST CHINESE ACADEMY OF FISHERIES SCI
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although inactivated vaccines and attenuated vaccines have played a good role in the prevention of IHNV, VHSV and SVCV, they are easy to cause residues in the breeding environment during their use, and may lead to pathogen resistance and virus mutations. form
In contrast, nucleic acid vaccine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • The invention also discloses application of PARP inhibitor PJ34 in preparation of anti-fish rhabdovirus products
  • The invention also discloses application of PARP inhibitor PJ34 in preparation of anti-fish rhabdovirus products
  • The invention also discloses application of PARP inhibitor PJ34 in preparation of anti-fish rhabdovirus products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1, the application of PARP inhibitor PJ34 in anti-fish rhabdovirus

[0034] 1. Experimental materials

[0035] 1.1 Cells and viruses

[0036]EPC cell ATCCCRL-2872; Infectious hematopoietic organ necrosis virus Sn1203 strain (referred to as IHNV-Sn1203 strain) (Genbank accession number: KC660147.1) (reference "Zhao Jingzhuang, Xu Liming, Ren Guangming, et al. Infectious hematopoietic organ necrosis virus Sn1203 Strain whole genome sequence and phylogenetic analysis[J]. Journal of Fisheries Science, 2020, v.33(02):4-12."); Viral hemorrhagic sepsis virus strain (VHSV-1387 for short) (ATCC VR1387); Carp Spring Viraemia Virus Shlj1 Strain (SVCV-Shlj1 for short) (Reference "Ji Feng. Prediction of Glycoprotein Spatial Structure and B Cell Epitope of Carp Spring Viremia Virus Shlj1 Strain [J]. Journal of Dalian Ocean University , 2017, 32(4):440-446.”).

[0037] 1.2 Reagents

[0038] Cell culture medium MEM (C11095500BT), trypsin (25200072), fetal bovine serum (1009...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of a PARP inhibitor PJ34 in preparation of an anti-fish rhabdovirus product. The invention provides an application of a PARP inhibitor PJ34 or a derivative thereof or a pharmaceutically acceptable salt thereof or a substance taking the PARP inhibitor PJ34 or the derivative thereof or the pharmaceutically acceptable salt thereof as an active ingredient in preparation of an anti-fish rhabdovirus product. In the invention, a plurality of PARP inhibitors are screened, and results show that the PARP inhibitor PJ34 can inhibit mRNA replication of IHNV, VHSV andSVCV viruses in cells and reduce titer (TCID50) of the IHNV, the VHSV and the SVCV viruses at the same time; and the inhibition effect of the PJ34 on the IHNV, the VHSV and the SVCV shows a dose-dependent relationship. The PARP inhibitor PJ34 is expected to become a novel drug for resisting fish rhabdovirus.

Description

technical field [0001] The invention relates to the field of aquaculture, in particular to the application of PARP inhibitor PJ34 in the preparation of anti-fish rhabdovirus products. Background technique [0002] Since 2010, the output of the world's aquaculture industry has grown rapidly. However, the spread of infectious diseases has seriously affected the healthy and sustainable development of aquaculture. The research and application of preventive and therapeutic drugs have become an urgent need for the aquaculture industry. [0003] Infectious hematopoietic necrosis (IHN) is one of the major diseases endangering salmon and trout farming in the world. It is caused by infectious hematopoietic necrosis virus (IHNV), which is a serious threat to 1. Acute infectious diseases of trout can usually cause 80%-100% mortality depending on the fish species, fish age, virus strains and breeding environment. [0004] Viral haemorrhagic septicaemia (VHS) is an infectious disease mai...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/473A61P31/14
CPCA61K31/473A61P31/14
Inventor 赵景壮徐黎明卢彤岩任广明邵轶智
Owner HEILONGJIANG RIVER FISHERY RES INST CHINESE ACADEMY OF FISHERIES SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap