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Pharmaceutical composition for treating ear mites and preparation method of pharmaceutical composition

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of inability to directly use ear mites and cannot be cured, and achieve high animal medication compliance, convenient administration, and strong curative effect. Effect

Active Publication Date: 2021-04-13
南京朗博特动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some other oral anthelmintic drugs on the market also have a therapeutic effect on ear mites, but they cannot be directly used on ear mites and cannot be cured

Method used

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  • Pharmaceutical composition for treating ear mites and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating ear mites and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating ear mites and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A novel pharmaceutical composition for treating ear mites, comprising the following raw materials in weight percentage: 0.5% of milbexime, 92.5% of solvent, 5.0% of solubilizer, and 2.0% of stabilizer.

[0029] In the present embodiment, the prescription adopted by the pharmaceutical composition for the novel treatment of ear mites is as follows:

[0030]

[0031] see figure 1 The preparation flow chart of the preparation method of the novel pharmaceutical composition for the treatment of ear mites comprises the following steps:

[0032] Process 1 Weighing

[0033] Process 2 Dosing

[0034] Add the prescribed amount of benzyl alcohol into the batching tank, add the prescribed amount of milbexime and polyethylene glycol cetostearyl ether, stir until dissolved; add liquid paraffin, and mix well.

[0035] Process 3 Filtration

[0036] The drug solution was sterilized and filtered through a 0.22 µm high-efficiency filter.

[0037] Process 4 Filling

[0038] Fill th...

Embodiment 2

[0042]

[0043] The preparation method is the same as in Example 1.

Embodiment 3

[0045]

[0046] The preparation method is the same as in Example 1.

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Abstract

The invention relates to the technical field of pharmaceutical compositions, in particular to a pharmaceutical composition for treating ear mites. The pharmaceutical composition is transparent milbemycin oxime ear drops, and comprises the following raw material medicines in percentages by weight: 0.1-1.0% of milbemycin oxime, 19.0-92.5% of a solvent, 2.0-50.0% of a solubilizer and 2.0-30.0% of a stabilizer. The ear drops provided by the invention are an innovative preparation for treating ear mites, can be dropped into ear canals of cats and dogs for use, directly act on ear mites, have an extremely strong curative effect on medium and severe ear mite infection, and are high in safety. The composition prepared by the invention has the characteristics of being convenient to administrate, accurate in dosage, lasting in effect and strong in curative effect, is non-irritant due to ear drop use, and has higher animal medicine taking compliance compared with oral medicines.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to a pharmaceutical composition for treating ear mites and a preparation method thereof. Background technique [0002] Otodectes cynotis, also known as ear scabies, is a common ear canal parasite in cats and dogs. Most cases are parasitic in the ear canal, and a few cases also appear in the head, neck and tail. Due to the short life cycle of ear mites, only about 18-28 days. The eggs of the ear mite turn into larvae after 4 days. Larvae become adults after passing through the pronymphal and secondary nymphal stages. Ear mites can fertilize and lay eggs immediately after becoming adults. And the vitality is strong, and it can survive in the environment for 5 to 17 days after leaving the host. Therefore, ear mites are highly contagious between cats and dogs. There can be thousands of ear mites in cat ear canals, and the number of ear mites in dog ear canals is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/06A61K31/365A61P27/16A61P33/14
CPCA61K9/08A61K9/0046A61K47/10A61K47/06A61K31/365A61P27/16A61P33/14
Inventor 刘利锋朱玉玲朱成强
Owner 南京朗博特动物药业有限公司
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