Traditional Chinese medicine concentrated pills and preparation method thereof

Abstract

The invention relates to traditional Chinese medicine concentrated pills and a preparation method thereof. The traditional Chinese medicine concentrated pills are prepared from traditional Chinese medicine extracts and hulless oat flour, and other pharmaceutic adjuvants can be added according to needs. It is further found that hulless oat flour and cellulose serving as other pharmaceutic adjuvants are mixed to serve as an auxiliary material used in the preparation process of the traditional Chinese medicine concentrated pills, the traditional Chinese medicine concentrated pills have more excellent technical effects, and the particularly preferred formula is as follows: 40-80 parts of traditional Chinese medicine extract, 5-40 parts of microcrystalline cellulose or / and powdery cellulose, and 5-40 parts of hulless oat flour.

Description

technical field [0001] The invention relates to the preparation of a traditional Chinese medicine preparation, which belongs to the field of medicine, and particularly relates to a concentrated traditional Chinese medicine pill and a preparation method thereof. Background technique [0002] Traditional Chinese medicine pills are a commonly used dosage form in the pharmaceutical field. Because they can meet the various requirements of medical preventive medicine, and have the advantages of accurate dosage, stable quality, and convenient administration, they have been widely used in research and development, production, and clinical practice. Traditional Chinese medicine pills refer to spherical or quasi-spherical preparations made of fine powder or extracts of medicinal materials plus suitable binders or other auxiliary materials, including traditional Chinese medicine honey pills, water honey pills, water pills, paste pills, wax pills, dripping pills, concentrated pills, etc....

AI Technical Summary

Problems solved by technology

The traditional pan-preparation process in traditional Chinese medicine pills can achieve pellet level and wide drug loading range, but it has strong experience, low yield, small production capacity, difficult operation, long production cycle, and polluting errors in the production process With the development of preparation equipment, the application is gradually reduced; while the plastic method has a high degree of mechanization, high yield, large production capacity, and low probability of errors, which is more suitable for large-scale production. This process is getting more and more popular in production. more widely used

[0006] The problems encountered in making pills with conventional excipients are: first, the drug-loading range of the preparation is narrow. Due to the large fluctuations in the yield of Chinese herbal medicines, the amount of drug extract in the unit preparation fluctuates greatly, and the drug-loading capacity is too high. Stretches, sticky pills, sticky knives, etc. appear, and the drug load is too low to easily break the strips and have poor plasticity, which seriously affects product quality and reduces production efficiency.

Second, the application rate of auxiliary materials is low. The main components of traditional Chinese medicine include alkaloids, sugars, glycosides, quinones, flavonoids, organic acids, tannins, proteins, etc. Among them, the major components that affect the formulation of the preparation are mainly polysaccharides, glycosides, Tannins, alkaloids, proteins, etc.

Fourth, the shape of the pills is poor and unsightly. The concentrated pills of traditional Chinese medicine are generally not round, which reduces the dependence of patients on medication. The high proportion of special-shaped pills has a great impact on the control of the difference in filling volume during the canning process and the maintenance of the filling machine.

[0007] Chinese patent CN1919272A discloses a concentrated traditional Chinese medicine pill, which records that it is made from dry powder of traditional Chinese medicine extract and microcrystalline cellulose. Soft, poorly balled technical issues

But buckwheat lacks glutenin and gliadin, buckwheat flour cannot make bread

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