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A kind of preparation method of loquat leaf ursolic acid cream

A technology of loquat leaf and ursolic acid, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of less research on dosage forms and applications, and improve the medicinal value. value, increased use, and the effect of enhancing development value

Active Publication Date: 2022-07-19
JILIN AGRI SCI & TECH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For now, in China, the pharmacological effects of loquat leaf ursolic acid have been thoroughly studied, but there are few studies on dosage forms and applications.

Method used

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  • A kind of preparation method of loquat leaf ursolic acid cream
  • A kind of preparation method of loquat leaf ursolic acid cream
  • A kind of preparation method of loquat leaf ursolic acid cream

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Experimental program
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Embodiment

[0026] Material

[0027] The loquat leaves were purchased from dried loquat leaves in Putian, Fujian Province on April 16, 2018, and were identified as the leaves of Eriobotrya Lindl.

[0028] 1.2 Accessories

[0029] The excipients used are shown in Table 1.

[0030] Table 1 Excipients

[0031]

[0032] 2 methods

[0033] 2.1 Extraction of ursolic acid from loquat leaves

[0034] 2.1.1 Preparation of loquat leaf ursolic acid extract

[0035] Weigh 80.0 g of crushed loquat leaf coarse powder and place it in a 1000 mL beaker, add 85% ethanol solution at a ratio of 1:10 (g / mL) to liquid to material, stir evenly, seal the mouth of the beaker with plastic wrap, sonicate The temperature was 70 °C and the ultrasonic power was 480 W after ultrasonic treatment for 30 min, then left for 1 h, suction filtration, and the collected filtrate was evaporated to dryness under reduced pressure to obtain loquat leaf ursolic acid extract.

[0036] 2.1.2 Purification of ursolic acid from...

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Abstract

The invention discloses a preparation method of loquat leaf ursolic acid cream. The loquat leaf ursolic acid cream is prepared by the following formula: 2 g of loquat leaf ursolic acid; 38 g of a composite oil phase; 2 g of a composite emulsifier ; Glycerin 15 g; Azone 2g; Paraben 0.1g; Purified water is added to 100g; Wherein, described composite emulsifier is by emulsifier-OP and sodium lauryl sulfate in a mass ratio of 1:1 Mixed. The composite oil phase is composed of 10 g of stearic acid, 5 g of glycerol monostearate, 15 g of petrolatum, 5 g of cetyl alcohol and 3 g of liquid paraffin. The invention adopts ultrasonic-assisted extraction of ursolic acid in loquat leaves, and prepares the ursolic acid from loquat leaves into a safe, effective, stable and controllable cream that is easy to use, comprehensively utilizes loquat leaf resources, and improves the medicinal research and development value of loquat leaves. , Increase the use of ursolic acid in loquat leaves, and improve the medicinal value of ursolic acid in loquat leaves.

Description

technical field [0001] The invention relates to the field of preparation of traditional Chinese medicine preparations, in particular to a preparation method of loquat leaf ursolic acid cream. Background technique [0002] Loquat leaves, also known as Ba Ye, have a mild gas and a slightly bitter taste, and can be harvested throughout the year. Loquat leaf is a traditional Chinese herbal medicine with a long history of medicinal use. It has antitussive, expectorant, antiasthmatic, anti-inflammatory, antioxidant and bacteriostatic effects. Modern pharmacological studies have shown that loquat leaves are not only low in toxicity, but also have antiviral, hypoglycemic and immunomodulatory effects. [0003] Ursolic acid (UA) is one of the functional substances in loquat leaves, and it has a wide range of biological activities. Experimental studies have shown that loquat leaf ursolic acid has various pharmacological effects such as antibacterial, antiviral, anticancer, hypoglycem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/56A61K36/73A61K47/12A61K47/14A61K47/06A61K47/10A61K47/20A61K47/22A61P31/04A61P31/10A61P31/12A61P35/00A61P3/10A61P25/20A61P1/16A61P29/00A61P39/06A61P17/18A61P17/00C07J63/00A61K127/00
CPCA61K9/107A61K9/0014A61K31/56A61K36/73A61K47/12A61K47/14A61K47/06A61K47/10A61K47/20A61K47/22A61P31/04A61P31/10A61P31/12A61P35/00A61P3/10A61P25/20A61P1/16A61P29/00A61P39/06A61P17/18A61P17/00C07J63/008
Inventor 陈冰罗阳邵啸
Owner JILIN AGRI SCI & TECH COLLEGE