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Preparation method of folium eriobotryae ursolic acid cream

A technology of loquat leaf and ursolic acid, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of less research on dosage forms and applications, and improve the medicinal value. Value, Ease of Use, Effects of Increased Use

Active Publication Date: 2021-04-27
JILIN AGRI SCI & TECH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For now, in China, the pharmacological effects of loquat leaf ursolic acid have been thoroughly studied, but there are few studies on dosage forms and applications.

Method used

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  • Preparation method of folium eriobotryae ursolic acid cream
  • Preparation method of folium eriobotryae ursolic acid cream
  • Preparation method of folium eriobotryae ursolic acid cream

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Embodiment

[0026] Material

[0027] The loquat leaves were purchased from dried loquat leaves in Putian, Fujian Province on April 16, 2018, and were identified as leaves of loquats of the genus Eriobotrya Lindl. in the family Rosaceae by teacher Li Yujie of Jilin Agricultural Science and Technology College.

[0028] 1.2 Excipients

[0029] The auxiliary materials used are shown in Table 1

[0030] Table 1 Excipients

[0031] Accessories batch number Manufacturer stearic acid 20171220 Tianjin Beichen Founder Reagent Factory Glyceryl monostearate 20180320 Shanghai Zhanyun Chemical Co., Ltd. cetyl alcohol 20180301 Wuxi Yatai United Chemical Co., Ltd. vaseline 20170710 Dezhou Chengze Disinfection Products Co., Ltd. liquid paraffin 20180720 Tianjin Zhiyuan Chemical Reagent Co., Ltd. Emulsifier-OP 20180723 Sinopharm Chemical Reagent Co., Ltd. Sodium dodecyl sulfate 20181201 Wuxi Yatai United Chemical Co., Ltd. lauryl a...

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Abstract

The invention discloses a preparation method of folium eriobotryae ursolic acid cream. The folium eriobotryae ursolic acid cream is prepared according to the following formula of 2g of folium eriobotryae ursolic acid, 38g of a composite oil phase, 2g of a composite emulsifier, 15g of glycerol, 2g of laurocapram, and 0.1g of ethylparaben, and purified water is added to 100g; composite emulsifier is obtained by mixing an emulsifier-OP and lauryl sodium sulfate according to a mass ratio of 1: 1; and the composite oil phase is composed of 10g of stearic acid, 5g of glycerin monostearate, 15g of Vaseline, 5g of hexadecanol and 3g of liquid paraffin. Ursolic acid in folium eriobotryae is extracted under the assistance of ultrasonic waves, the folium eriobotryae ursolic acid is prepared into cream which is safe, effective, stable, controllable and convenient to use, folium eriobotryae resources are comprehensively utilized, the medicinal research and development value of the folium eriobotryae is improved, the application of the folium eriobotryae ursolic acid is increased, and the medicinal value of the folium eriobotryae ursolic acid id improved.

Description

technical field [0001] The invention relates to the field of preparation of traditional Chinese medicine preparations, in particular to a preparation method of loquat leaf ursolic acid cream. Background technique [0002] Loquat leaves, also known as bay leaves, have a slight smell and a slightly bitter taste, and can be harvested throughout the year. Loquat leaf is a traditional folk Chinese herbal medicine with a long history of medicinal use. It has antitussive, expectorant, antiasthmatic, anti-inflammatory, antioxidant and antibacterial effects. Modern pharmacological studies have shown that loquat leaves are not only low in toxicity, but also have antiviral, hypoglycemic and immunoregulatory effects. [0003] Ursolic acid (UA) is one of the functional substances in loquat leaves, which has a wide range of biological activities. Experimental studies have shown that loquat leaf ursolic acid has various pharmacological effects in the body such as antibacterial, antiviral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/56A61K36/73A61K47/12A61K47/14A61K47/06A61K47/10A61K47/20A61K47/22A61P31/04A61P31/10A61P31/12A61P35/00A61P3/10A61P25/20A61P1/16A61P29/00A61P39/06A61P17/18A61P17/00C07J63/00A61K127/00
CPCA61K9/107A61K9/0014A61K31/56A61K36/73A61K47/12A61K47/14A61K47/06A61K47/10A61K47/20A61K47/22A61P31/04A61P31/10A61P31/12A61P35/00A61P3/10A61P25/20A61P1/16A61P29/00A61P39/06A61P17/18A61P17/00C07J63/008
Inventor 陈冰罗阳邵啸
Owner JILIN AGRI SCI & TECH COLLEGE