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Mecobalamin tablet and preparation method thereof

A technology of methylcobalamin tablets and methylcobalamin, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of light instability, strong hygroscopicity, and active ingredient content. Low-level problems, to achieve the effect of good stability and content uniformity

Inactive Publication Date: 2021-04-30
北京民康百草医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Methylcobalamin tablets have strong hygroscopicity, are unstable to light, and the content of active ingredients is low, so the problem of content uniformity restricts the large-scale production of methylcobalamin tablets

Method used

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  • Mecobalamin tablet and preparation method thereof
  • Mecobalamin tablet and preparation method thereof
  • Mecobalamin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of methylcobalamin tablet (one)

[0024] The methylcobalamin tablets of the formula in Table 1 were prepared as follows.

[0025] Table 1

[0026]

[0027]

[0028] (1) Weigh the formula quantities of raw and auxiliary materials A, B, C, D, F, G, and H.

[0029] (2) Pre-mixing: first mix A with an equal weight of D for 5 minutes, pass through a 60-mesh sieve to disperse once, then mix for 5 minutes, and then mix with all the remaining D for 5 minutes, and pass through a 60-mesh sieve to disperse twice. Then take 1 / 3 of the formula amount of C to wash the sieve and mix it with the mixture of A and D for 5 minutes, pass through a 60-mesh sieve to disperse for 2 times, and mix for 5 minutes to obtain a uniformly mixed powder of color and luster, which is collected and used for later use.

[0030] (3) Premixing: successively place 1 / 3 of the formula amount of C, the mixed powder obtained in step (2), and the remaining 1 / 3 of C in a wet ...

Embodiment 2

[0033] Embodiment 2: the preparation of methylcobalamin tablet (two)

[0034] The methylcobalamin tablets of the formula in Table 2 were prepared as follows.

[0035] Table 2

[0036]

[0037]

[0038] (1) Weigh the formula quantities of raw and auxiliary materials A, B, C, D, F, G, and H.

[0039] (2) Pre-mixing: first mix A with an equal weight of D for 5 minutes, pass through a 60-mesh sieve to disperse once, then mix for 5 minutes, and then mix with all the remaining D for 5 minutes, and pass through a 60-mesh sieve to disperse twice. Then take 1 / 3 of the formula amount of C to wash the sieve and mix it with the mixture of A and D for 5 minutes, pass through a 60-mesh sieve to disperse for 2 times, and mix for 5 minutes to obtain a uniformly mixed powder of color and luster, which is collected and used for later use.

[0040] (3) Pre-mixing: successively place 1 / 3 of the formula amount of C, the mixed powder obtained in step (2), and the remaining 1 / 3 of C in a wet...

Embodiment 3

[0043] Embodiment 3: the preparation of methylcobalamin tablet (three)

[0044] The methylcobalamin tablets of the formula in Table 3 were prepared as follows.

[0045] table 3

[0046]

[0047] (1) Weigh the formula quantities of raw and auxiliary materials A, B, C, D, F, G, and H.

[0048](2) Pre-mixing: first mix A with an equal weight of D for 5 minutes, pass through a 60-mesh sieve to disperse for 2 times, then mix for 5 minutes, and then mix with all the remaining D for 5 minutes, and pass through a 60-mesh sieve to disperse 2 times. Then take 1 / 3 of the formula amount of C to wash the sieve and mix it with the mixture of A and D for 5 minutes, pass through a 60-mesh sieve to disperse for 2 times, and mix for 5 minutes to obtain a uniformly mixed powder of color and luster, which is collected and used for later use.

[0049] (3) Pre-mixing: successively place 1 / 3 of the formula amount of C, the mixed powder obtained in step (2), and the remaining 1 / 3 of C in the wet...

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Abstract

The invention belongs to the technical field of medicinal preparations, and relates to mecobalamin tablet and a preparation method thereof. The mecobalamin tablet comprises the following components in parts by weight: 0.8-1.2 parts of mecobalamin, 15-18 parts of starch, 55-65 parts of microcrystalline cellulose, 100-110 parts of lactose, 0.4-0.5 part of calcium stearate and 8-10 parts of coating powder, wherein the coating powder is selected from one or more of titanium dioxide, red iron oxide, hydroxypropyl methylcellulose, polyethylene glycol and yellow iron oxide. By utilizing the mecobalamin tablet and the preparation method thereof, the prepared mecobalamin tablet has better stability and content uniformity.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a methylcobalamin tablet and a preparation method thereof. Background technique [0002] Methylcobalamin (Methylcobalamin) is a dark red crystal or crystalline powder, a coenzyme vitamin B12, mainly used in clinical medicine to treat peripheral nerve diseases and macrocytic anemia caused by vitamin B12 deficiency. Compared with other coenzyme-type vitamin B12 drugs, mecobalamin has good conductivity to nerve tissue, and is a more effective drug for the treatment of peripheral nerve diseases. Methylcobalamin tablets have strong hygroscopicity, are unstable to light, and have a low content of active ingredients, so the problem of content uniformity restricts the large-scale production of methylcobalamin tablets. From the point of view of quality by design, it is very important to mix the materials in the early stage of the preparation of methylcobalamin tablets u...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/32A61K31/714A61K47/38A61K47/36A61K47/26A61P7/06A61P25/02
CPCA61K9/2866A61K9/2853A61K9/2813A61K9/2059A61K9/2054A61K9/2018A61K9/2095A61K31/714A61P25/02A61P7/06
Inventor 陈同升谷金秒马海涛邓青梅
Owner 北京民康百草医药科技有限公司
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