Method for synthesizing 2S,3R-p-methylsulfonephenylserine

Abstract

The invention discloses a method for synthesizing 2S,3R-p-methylsulfonephenylserine, wherein cheap p-methylsulfonebenzaldehyde and threonine are used as substrates, transaldolase is applied to drive a reaction, and acetaldehyde dehydrogenase and NAD oxidase are simultaneously added to eliminate the generation of by-product acetaldehyde. According to the invention, the method has mild reaction conditions, can greatly reduce the production cost, and can perform large-scale reactions.

Description

technical field [0001] The invention relates to the fields of chemical industry and pharmacy, in particular to a synthesis method of chiral 2S, 3R-p-thymphenylphenylserine. Background technique [0002] 2S,3R-P-thymphenylphenylserine is an important chemical raw material, mainly used in the synthesis of chemicals such as broad-spectrum antibacterial drug Florfenicol, and its structural formula is as follows: [0003] [0004] The current synthesis of chiral 2S,3R-p-thymphenylphenylserine is mainly realized by chemical method, which is prepared by condensation and split multi-step process. In industrial production, the chemical method steps are cumbersome and pollute the environment. Therefore, the development of a more environmentally friendly asymmetric synthesis method of 2S,3R-p-thymphenylphenylserine has important application value. [0005] Biologists have also made some attempts on the asymmetric synthesis of chiral 2S,3R-p-thymphenylphenylserine. Using p-thiamphe...

AI Technical Summary

Problems solved by technology

[0009] However, experiments have shown that in the case of relatively high concentrations, the reaction is difficult, and it is difficult to carry out large-scale reactions

Images