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Membrane carrier for test kit and test kit

A kit and carrier technology, which is applied to the field of membrane carriers for test kits and test kits, can solve the problems of time change, flow rate difference of liquid sample flow, etc., and achieve the effect of improving detection sensitivity

Pending Publication Date: 2021-04-30
DENKA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, nitrocellulose membranes are derived from natural materials, and the pore size and connection between pores are not consistent, so the flow rate of liquid samples flowing in each membrane will be different.
If the flow rate is different, the time it takes to detect the substance to be tested will also change, and as a result, the substance to be tested may be erroneously judged not to be detected before it binds

Method used

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  • Membrane carrier for test kit and test kit
  • Membrane carrier for test kit and test kit
  • Membrane carrier for test kit and test kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156]

[0157] A cycloolefin polymer sheet (manufactured by Zeon Corporation, ZeonorZF-14, film thickness 200 μm) was subjected to thermal embossing to make the diameter of the bottom surface of the concave-convex structure A (protrusion) (hereinafter sometimes referred to as "the diameter of the protrusion") or "diameter") is 30 μm, and the height of the uneven structure A (protrusion) (hereinafter sometimes referred to as "height") is 30 μm, the average distance between the protrusions is 50 μm, and image 3 A membrane carrier arranged in such a triangular arrangement.

[0158] Here, when thermal imprinting is applied, the fine uneven structure B is formed on the surface of the uneven structure A (protrusion) by using an etched mold (mold), and the protrusion 8 formed with the fine uneven structure B is , the maximum peak height Rp of the roughness curve and the average length RSm of the elements of the roughness curve are adjusted to the values ​​shown in Table 1, respec...

Embodiment 2～6

[0171] By adjusting the etching treatment conditions for the mold (specifically, the concentration of the etching solution and the immersion time), the maximum peak height Rp of the roughness curve and the average value of the roughness curve elements of the protrusion 8 formed with the fine uneven structure B The same experiment as in Example 1 was carried out except that the length RSm was adjusted to the values ​​shown in Table 1, respectively.

[0172] The obtained results are shown in Table 1.

Embodiment 7～12

[0174] By adjusting the etching treatment conditions for the mold, the maximum peak height Rp of the roughness curve and the average length RSm of the roughness curve elements of the protruding portion 8 formed with the fine concave-convex structure B are adjusted to the values ​​shown in Table 1, respectively, and Use 3-glycidoxypropyltrimethoxysilane (also referred to as GOPTS) instead of 3-aminopropyltriethoxysilane (also referred to as APTES), and implement the same procedure as in Example 1, respectively. experiment.

[0175] The obtained results are shown in Table 1.

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Abstract

This test kit membrane carrier is for detecting a to-be-detected substance in a liquid sample, and is provided with a flow channel that has a detection zone, wherein: the flow channel has a relief structure A having projections; at least in the detection zone, the projections each have, formed on the surface thereof, a minute relief structure B; the minute relief structure B has a silane coupling agent attached to the surface thereof; the projections having the minute relief structure B formed thereon have a maximum ridge height Rp of 0.005-10 [Mu]m in a roughness curve as measured using a scanning electron microscope for three-dimensional roughness analysis in conformity to JIS B0601: 2013; and the average length RSm of roughness curve elements is 0.01-15 [Mu]m.

Description

technical field [0001] The invention relates to a membrane carrier for a test kit and a test kit. Background technique [0002] In recent years, Point of Care Testing (POCT, clinical point-of-care testing) reagents that measure the prevalence of infectious diseases, pregnancy, blood sugar levels, etc. by using antigen-antibody reactions, etc., have attracted attention. POCT reagents are, for example, tests that are performed on the subject's side, or that are performed by the subject himself, and have the characteristics of being able to discriminate results in a short time, and being easy to use and inexpensive. Due to these characteristics, it is often used for examinations at the stage of mild symptoms, regular examinations, etc., and it is also an important examination tool in home medical care that is expected to increase in the future. [0003] For many POCT reagents, determination is made by introducing a liquid sample such as blood into a test kit and detecting a sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/547G01N37/00
CPCG01N33/54366G01N33/54313G01N33/558G01N33/54388G01N33/54389G01N33/543G01N33/547G01N33/5306
Inventor 青山周平秋山雄斗
Owner DENKA CO LTD