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Composition for relieving cough and reducing sputum and preparation method thereof

A technology for relieving cough and removing phlegm and a composition is applied in the field of the composition for relieving cough and removing phlegm and its preparation, and can solve the problems of poor patient experience, disappearance and high temperature

Active Publication Date: 2021-05-04
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process is not only long, time-consuming and energy-consuming, but also because of the high temperature and long heating time, the content and activity of various heat-sensitive components in the extract decrease or even disappear, and the volatilization of flavor substances leads to poor taste of the product
In addition, the extracts of Chinese herbal medicines and their compositions, even if they are water extracts, have poor resolubility after adding water, it is difficult to form a clear and stable solution, and the experience of patients is poor.

Method used

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  • Composition for relieving cough and reducing sputum and preparation method thereof
  • Composition for relieving cough and reducing sputum and preparation method thereof
  • Composition for relieving cough and reducing sputum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0066] Preparation of reference solution: Take an appropriate amount of psoralen reference substance, accurately weigh it, put it in a 50mL volumetric flask, add an appropriate amount of methanol, and ultrasonically (power 100W, frequency 40kHz) to dissolve (water temperature rises about 1°C) , cooled to room temperature, added methanol to the mark, shaken well, and prepared a solution with a concentration of psoralen of 0.188 mg / mL.

[0067] Preparation of the test solution: take 0.5g of the test sample, accurately weigh it, place it in a 50mL conical flask with a stopper, accurately add 30mL of 50% methanol solution, extract by ultrasonic (power 100W, frequency 40kHz) for 30min, filter, The solvent was recovered from the filtrate to dryness, the residue was dissolved in methanol, transferred to a 5mL volumetric flask, diluted to the mark with methanol, shaken up, filtered through a 0.22 μm microporous membrane, and the subsequent filtrate was taken as the test solution.

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Embodiment 1

[0089] Example 1 A kind of composition with the effect of relieving cough and resolving phlegm

[0090] The composition described in this embodiment is made of the following traditional Chinese medicine composition as raw material:

[0091] 20 parts by weight of five-finger peach, 5 parts by weight of Polygonatum japonica, 2 parts by weight of mulberry leaves and 2 parts by weight of Luo Han Guo; wherein 1 part by weight = 1 kg.

[0092] According to the optimized process of Research Example 1, continuous extraction and concentration were carried out in a continuous extraction and separation concentrator, and the concentrated solution was spray-dried (inlet air temperature 160°C, outlet air temperature 60°C) to obtain.

Embodiment 2

[0093] Example 2 A kind of composition with the effect of relieving cough and resolving phlegm

[0094] The composition described in this example is made of the following traditional Chinese medicine composition as a raw material:

[0095] 30 parts by weight of five-finger peach, 10 parts by weight of Polygonatum japonica, 5 parts by weight of mulberry leaves and 5 parts by weight of Luo Han Guo; wherein 1 part by weight = 1 kg.

[0096] According to the optimized process of Research Example 1, continuous extraction and concentration were carried out in a continuous extraction and separation concentrator, and the concentrated solution was spray-dried (inlet air temperature 165°C, outlet air temperature 65°C) to obtain.

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition with effects of reducing sputum and relieving cough. The traditional Chinese medicine composition is prepared from 20-50 parts by weight of radix fici simplicissimae, 5-25 parts by weight of radix polygonati officinalis, 2-15 parts by weight of folium mori and 2-15 parts by weight of fructus momordicae. The invention further provides a composition prepared from the traditional Chinese medicine composition and a preparation method and application of the composition.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and traditional Chinese medicine preparation, and particularly relates to a composition for relieving cough and resolving phlegm and a preparation method thereof. Background technique [0002] Cough is a common respiratory symptom caused by inflammation, foreign body, physical or chemical irritation of the trachea, bronchial mucosa, or pleura. Although cough is a non-specific symptom, it is a manifestation of the body's active response to the disease, which can reduce the damage of pathogenic factors to the respiratory tract and relieve the disease; however, excessively frequent and severe coughing can cause congestion and edema of the airway mucosa, leading to respiratory tract bleeding, and even induce Spontaneous pneumothorax, etc. In addition, cough can also spread infection in the respiratory tract; long-term cough stimulation, the cough center will remain in a highly excited stat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P11/14A61P11/00A61P11/10
CPCA61K36/60A61K36/8969A61K36/605A61K36/42A61P11/14A61P11/00A61P11/10A61K2236/331A61K2236/53A61K2236/51A61K2300/00
Inventor 蔡树杏李楚源王德勤郭海彪李淑如
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE