Chemical exchange saturation transfer quantitative method and device for magnetic resonance and medium

Abstract

The invention discloses a chemical exchange saturation transfer quantitative method and device for magnetic resonance and a medium, and belongs to the field of biomedical engineering. The chemical exchange saturation transfer quantitative method comprises the following steps of: acquiring a longitudinal relaxation rate of water; presetting a deformation formula for calculating the spin lock relaxation rate of water on the basis of an unsteady-state experiment condition, wherein at least one deformation parameter of the deformation formula is a ratio of a saturation signal to an unsaturation reference signal under the unsteady-state experiment condition; acquiring a plurality of parameters under an unsteady state experiment condition, calculating a deformation formula according to the parameters, and acquiring the spin lock relaxation rate of water; based on the longitudinal relaxation rate of water and the spin lock relaxation rate of water, acquiring a magnetic resonance chemical exchange saturation transfer signal under a steady-state experiment condition; and acquiring the magnetic resonance chemical exchange saturation transfer effect under the steady-state experiment condition based on the signal. According to the chemical exchange saturation transfer quantitative method and the device, the steady-state CEST signal can be calculated and obtained based on the unsteady-state CEST signal, so that the influence of the imaging parameter on a CEST quantitative result is removed, and the accuracy of CEST quantification is improved.

Description

technical field [0001] The application relates to the field of biomedical engineering, in particular to a chemical exchange saturation transfer quantitative method, device and medium for magnetic resonance. Background technique [0002] Magnetic resonance chemical exchange saturation transfer (CEST) imaging is an important imaging method for non-invasively obtaining molecular information of biological tissues using endogenous or exogenous CEST contrast agents. Sufficient saturation of the CEST contrast agent and sufficient recovery of the water molecule signal after saturation are necessary conditions for obtaining a steady-state CEST signal, which determine the accuracy of the quantification of the CEST effect. [0003] The quantification of the CEST effect is very complex, affected by many factors, and closely related to important imaging parameters such as saturation time (Ts) and recovery time (Td), that is, the quantitative results of CEST are highly dependent on imagin...

AI Technical Summary

Problems solved by technology

However, the saturation time is limited by factors such as the hardware system and specific absorption rate, and long-term saturation and recovery will greatly increase the scan time, which is very difficult in practical applications

In the prior art, most CEST imaging studies are usually carried out under conditions of short saturation time and recovery time (i.e., under unsteady experimental conditions), which cannot guarantee sufficient saturation and recovery, and the obtained CEST signal is also in an unsteady state. This leads to an underestimation of the CEST effect, preventing accurate and stable CEST quantification

Images