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Application of rapamycin in preparation of medicine for treating otitis media

A technology of rapamycin and otitis media, which is applied in the application field of rapamycin in the preparation of medicines for the treatment of otitis media, to achieve the effects of reducing accumulation, reducing inflammation and hearing loss, and having a remarkable therapeutic effect

Pending Publication Date: 2021-05-07
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the use of rapamycin in the treatment of otitis media

Method used

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  • Application of rapamycin in preparation of medicine for treating otitis media
  • Application of rapamycin in preparation of medicine for treating otitis media
  • Application of rapamycin in preparation of medicine for treating otitis media

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] 1. OM mouse model construction and RPM treatment

[0022] Tlr2tm1Kir (Tlr2 - / - ) mice (derived from Jackon Lab) were randomly divided into 4 groups, 5 in each group, and each group of mice was administered with the following drugs:

[0023] NS+DMSO group: normal saline+0.0032%DMSO;

[0024] PGPS group: normal saline + 60 μg PGPS;

[0025] PGPS+0.35μM RPM group: normal saline+60μgPGPS+0.0032%DMSO+0.35μM RPM;

[0026] PGPS+0.7μM RPM group: normal saline+60μgPGPS+0.0032%DMSO+0.7μM RPM;

[0027] The drugs of each group were uniformly injected into the middle ear of the right ear of the mice through tympanic membrane puncture, and the injection dose was 10 μL. The function and mechanism of the middle ear and inner ear tissues of the mice were studied on the 3rd day after injection.

[0028] 2. Auditory Brainstem Response (ABR) and Tympanometry

[0029] The ABR and tympanometry of experimental mice in each group were evaluated on day 3 after injection.

[0030] The ABR ...

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Abstract

The invention discloses application of rapamycin in preparation of a medicine for treating otitis media, and belongs to the technical field of medicines. The rapamycin can relieve otitis media inflammation and hearing loss and reduce accumulation of autophagy protein LC3-II and autophagy substrate protein p62, and has remarkable treatment effects; and the rapamycin has no renal toxicity and has wide prospects in research and development of the medicine for treating the otitis media.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of rapamycin in the preparation of medicines for treating otitis media. Background technique [0002] Otitis media (OM) is an inflammatory lesion involving all or part of the structure of the middle ear (including the eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cell), and is one of the most common clinical diseases in children. Serious complications inside and outside. The pathogenesis of OM is related to various factors such as immune system dysfunction, genetic susceptibility, pathogen exposure, Eustachian tube dysfunction, etc. The exact pathogenesis is still unclear. [0003] Rapamycin (RPM) is a new type of macrolide immunosuppressant with no nephrotoxicity and few side effects. It can resist fungi and inhibit tumor growth. It can also block signal transduction through different cytokine receptors. Blocking the progre...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61P27/16
CPCA61K31/436A61P27/16
Inventor 李博郑庆印赵彤郑体花张肖林奎丽红
Owner BINZHOU MEDICAL COLLEGE