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Compositions and methods for dental care

A composition and technology for teeth, applied in the field of compositions and methods of dental care, and capable of solving problems such as hypersensitivity, tooth decay, sensitivity and the like

Pending Publication Date: 2021-05-07
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, hidden dentin is exposed due to chemical demineralization, creating problems such as hypersensitivity and increased sensitivity to cavities that far outweigh any cosmetic benefits

Method used

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  • Compositions and methods for dental care
  • Compositions and methods for dental care
  • Compositions and methods for dental care

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0328]Tooth discoloration is a common aesthetic concern for many people, for which dental professionals and the public spend a great deal of time and money improving the appearance of stained teeth. Depending on the origin and location of the stain deposits, tooth discoloration can be divided into different categories, which also facilitates the development of targeted treatments. The categories described include: (i) extrinsic discoloration, where the discoloration is deposited on the outer surface of the tooth or in the film layer, such as tea, coffee, tobacco, metals, and salt constituents (copper, sulphides) of dietary products; (ii) intrinsic Staining in which the optical properties of the tooth are altered due to structural changes in the dentin due to aging, genetic factors, leakage of root canal treatment materials, or metabolic diseases, eg, uroalkali, congenital erythrocytosis Generative porphyria, congenital hyperbilirubinemia, enamel insufficiency, dentin insuffici...

Embodiment 2

[0448] Example 2. Dental hypersensitivity

[0449] Dental hypersensitivity (DH) is a common oral health condition affecting the majority of adults worldwide. In the U.S. alone, spending on allergies, toothpaste, clinical toothpaste and gel, and mouthwash totals about $10 billion. Despite a plethora of over-the-counter and clinical products, treatment options are limited, and allergies remain a leading cause of dental discomfort and an underlying cause of gingivitis and tooth loss. Dental hypersensitivity is caused by exposure of dentin due to demineralization of the protective cementum or enamel covering the tooth surface. When the dentinal tubules are exposed, the nerve fibers in the pulp or dentin precursor are stimulated by the displacement of fluid and trigger pain. Pain-inducing stimuli can be thermal, chemical, or mechanical. At present, there is still no effective drug to completely solve the patient's discomfort to dental hypersensitivity. Over-the-counter products...

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Abstract

Disclosed herein are compositions and methods for their use in treating dental disorders, whitening teeth, restoring and retaining the tooth structure and restoring the mineral content of the tooth-mineral loss due to demineralization, wherein the compositions include a first formulation that includes a polypeptide effective to treat a dental disorder and / or whiten teeth, and one or more further formulations including at least one calcium ion source and / or at least one phosphate ion source, wherein the first formulation is configured to release the polypeptide more rapidly than Ca2+ is released from the at least one calcium ion source and PO4 3- is released from the at least one phosphate ion source.

Description

[0001] cross reference [0002] This application claims priority to U.S. Provisional Application Patent No. 62 / 725,160, filed August 30, 2018, and U.S. Provisional Application Patent No. 62 / 758,230, filed November 9, 2018, each of which is incorporated by reference in its entirety included here. Background technique [0003] Demineralization (loss of mineral content on the tooth surface) is the leading cause of most dental diseases. Mineral loss can be caused by an acidic diet, dry mouth, tooth whitening, tooth wear, and dental caries caused by acid-producing bacteria. Left untreated, demineralization can lead to problems ranging from tooth sensitivity to pain in extreme cases to systemic infections such as heart disease. Demineralization is one of the most common causes of tooth loss. Dental hypersensitivity (DH) is a common oral health problem affecting the majority of adults worldwide. In the United States alone, spending on allergies, toothpaste, clinical patches and g...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61Q11/00A61Q11/02A61K8/30A61K8/00C07K14/47C07K14/78
CPCA61K8/64A61Q11/00C07K14/47C07K14/78A61K8/24A61K8/19A61K2800/882A61K2800/92
Inventor 穆罕默德·萨尔维德尼兹·塔尼尔·尤塞索伊汉森·郭·方萨米·道根
Owner UNIV OF WASHINGTON
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