Synthesis method of benzofuran compound

Abstract

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, and has the advantages of cheap and easily available initial raw materials, mild reaction conditions, wide substrate range, wide industrial application prospect and the like.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, and in particular relates to a synthesis method of benzofuran compounds. Background technique [0002] The benzofuran skeleton is a common moiety in many biologically active natural and therapeutic products. At the same time, the skeleton structure containing benzofuran is an important target of drug research. After modification with different substituents, it can be used as a very important heterocyclic pharmacophore, including candidate drugs defined in clinical and preclinical studies, which can have such Anti-HIV, anti-cancer, anti-depression, anti-arrhythmia and other effects. In view of the important role of heterocyclic aromatic compounds, general methods for the synthesis of biologically active compounds such as benzofurans have become the focus of organic synthetic chemists. [0003] Sulfur ylides have been widely used as carbene substitutes in transition metal-catalyzed organ...

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Problems solved by technology

[0015] The above synthesis method does not involve the synthesis of benzofuran compounds in which sulfur ylides participate, and the above methods all use noble metal catalysts. The noble metal catalyzed cyclocoupling increases the corresponding operating costs for industrial production, and the economical practicability is limited accordingly.

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