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Preventive and/or therapeutic agent for clostridium difficile infection

A technology of Clostridium difficile infection and therapeutic agent, which is applied in the direction of antibacterial drugs, functions of food ingredients, medical preparations containing active ingredients, etc., and can solve the problems of low CDI and low incidence

Pending Publication Date: 2021-05-18
NUTRI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in medical institutions where antimicrobials are misused and infection management is not adequately managed, it is considered a problem due to the low awareness and knowledge of CDI, so most of the problems are due to the lack of proper diagnosis of this disease and the apparent low incidence

Method used

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  • Preventive and/or therapeutic agent for clostridium difficile infection
  • Preventive and/or therapeutic agent for clostridium difficile infection
  • Preventive and/or therapeutic agent for clostridium difficile infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] [Example 1] Clostridium difficile infection defense test of lactic acid bacteria EF-2001 strain

[0073] Using a Clostridium difficile (Clostridium difficile) infection model, a drink containing lactic acid bacteria was orally administered, and the defense effect against Clostridium difficile infection was evaluated by indicators such as survival rate.

[0074] (Materials and methods)

[0075] Measured substance and medium

[0076] ·Measured substance

[0077] Name: Lactic acid bacteria powder EF-2001 (Japan Berumu Co., Ltd.) (heat-sterilized Enterococcus faecalis (E.faecalis), diameter 500nm=0.5μm)

[0078] Appearance: brown powder

[0079] Storage conditions: room temperature, shading, moisture-proof

[0080] Management temperature: 18.0~28.0℃

[0081] ·medium

[0082] Name: water for injection

[0083] Storage conditions: room temperature

[0084] Management temperature: 18.0-28.0℃

[0085] Manufacturer: Taitaku Pharmaceutical Factory Co., Ltd.

[0086] Det...

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PUM

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Abstract

Provided is a novel preventive and / or therapeutic agent for Clostridium difficile infection. It has been discovered that bacteria belonging to the genus Enterococcus are capable of preventing and / or curing Clostridium difficile infection. Disclosed herein are: an agent that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus; a medicinal product that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus; and a food product that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus.

Description

technical field [0001] The present invention relates to prophylactic and / or therapeutic agents for Clostridium difficile infection. Background technique [0002] Clostridium difficile infection (CDI) is mostly caused by damage to the bacterial flora of the digestive tract caused by the use of antibacterial drugs. Most of them are caused by the high use of antimicrobials, increasing age, and the presence or absence of underlying diseases. [0003] Most of CDI is gastrointestinal infection, and the symptoms are mostly diarrhea and abdominal pain, accompanied by fever and leukocytosis. If it develops into severe disease, it may be caused by toxic megacolon, intestinal obstruction, and perforation of gastrointestinal tract, which may lead to death. [0004] It has been confirmed that there are "carriers" who maintain the presence of C. difficile in the digestive tract without showing symptoms, and such "carriers" are more common in hospitalized patients who use a lot of antibac...

Claims

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Application Information

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IPC IPC(8): A61K35/744A23L33/135A61P31/04
CPCA61K35/744A23L33/135A61P31/04A23V2002/00A23V2200/324A61K9/0053
Inventor 川口晋加藤美穗
Owner NUTRI CO LTD
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