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57 results about "Clostridium Infections" patented technology

Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents

The present invention relates to the development of a targeted delivery system for the oral delivery of probiotics or therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn's disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension.
Owner:THERABIOME

Antibodies for the treatment of Clostridium difficile-associated infection and disease

Provided herein are reagents, compositions, and therapies with which to treat Clostridium difficile infection and related disease conditions and pathologies, such as Clostridium difficile-associated diarrhea, resulting from infection by Clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and / or toxin B of C difficile and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.
Owner:PROGENICS PHARMA INC

Hybridoma cell strain secreting tetanus exotoxin monoclonal antibody, monoclonal antibody prepared by same, Fab antibody and application

InactiveCN102690789AGood effectHas the effect of neutralizing tetanus exotoxinAntibacterial agentsFungiClostridium tetaniTotal rna
The invention relates to a mouse hybridoma cell strain secreting a clostridium tetani bacillus exotoxin monoclonal antibody, wherein the strain has a preservation number of CCTCC (China Center for Type Culture Collection) NO. C201257. The invention further relates to a clostridium tetani bacillus exotoxin monoclonal antibody prepared by the mouse hybridoma cell strain; the invention further provides an Fab antibody, comprising a kappa chain and an Fd chain; the kappa chain and the Fd chain are obtained by amplifying from total RNA (ribonucleic acid) of the hybridoma cell strain. The invention further relates to a medicine for preventing or treating clostridium tetani bacillus infection, comprising the clostridium tetani bacillus exotoxin monoclonal antibody and / or the Fab antibody, and a pharmaceutically acceptable carrier. According to the invention, a monoclonal antibody for effectively neutralizing tetanus exotoxin is screened with natural tetanus exotoxin, and an Fab gene engineering antibody which is produced by large scale in vitro and which has toxin neutralizing effect is prepared with a gene engineering antibody technology on the basis of the monoclonal antibody.
Owner:ARMY MEDICAL UNIV +1

Clostridium difficile-specific antibodies and uses thereof

The present invention is directed to Clostridium difficile toxin-specific antibodies, compositions, and uses thereof. The anti-toxin antibodies may be specific for either TcdA or TcdB. The invention also includes methods of treating a Clostridium difficile infection, methods of capturing Clostridium difficile toxins, and methods of detecting Clostridium difficile toxins.
Owner:NAT RES COUNCIL OF CANADA

Compositions and methods for prophylaxis and therapy of clostridium difficile infection

Provided are compositions and methods for prophylaxis and / or therapy of C. difficile infection, and for inhibiting dissemination of C. difficile spores. The compositions contain C. difficile proteins, including distinct proteins and fusions of C. difficile CD 1067, BclA1, SleC, CotA, Spl7, FliC, FliD, CD toxin A, CD toxin B, and combinations thereof. The methods include prophylaxis and / or therapy of C. difficile infection by administering to a subject in need a composition that includes the C. difficile protein(s).
Owner:THE ROCKEFELLER UNIV

Halogenated salicylanilides for treating clostridium infections

The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.
Owner:UNION THERAPEUTICS AS

Tetanus toxin-resistant neutralizing antibody as well as preparation and application thereof

The invention discloses a tetanus toxin-resistant neutralizing antibody as well as preparation and application thereof. The antibody can be used for preventing, treating and diagnosing tetanus infection and / or treating one or more symptoms mediated by clostridium tetani infection. The invention further provides a method for producing an antibody capable of combining with tetanus toxin immunologically specifically.
Owner:ZHUHAI TRINOMAB BIOTECHNOLOGY CO LTD

Methods and compositions for the treatment and/or prophylaxis of clostridium difficile associated disease

The present invention relates to methods and compositions for the treatment and / or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and / or a C. difficile endospore antigen.
Owner:IMMURON

Recombinant alpha protein for inhibiting clostridium perfringens infection and preparation method and application thereof

The invention discloses recombinant alpha protein for inhibiting clostridium perfringens infection and a preparation method and application thereof. The recombinant alpha protein is shown in (a) or (b) or (c), wherein the protein in (a) is composed of amino acid sequences shown as SEQ ID No.2; the protein in (b) is composed of amino acid sequences shown at the sites No.51-No.353 of SEQ ID No.2; the fusion protein in (c) is obtained by fusing protein tags at carboxyl terminals or / and amino terminals of the protein shown in (a) or (b). The recombinant alpha protein enables animals to have a higher serum antibody level and resist attack of clostridium perfringens after the animals are immunized with the recombinant alpha protein. The recombinant alpha protein is good in solubility and easy to purify and can serve as a diagnostic antigen to be prepared into a monoclonal antibody or be used for further research on protein functions and conformation relations.
Owner:CHINA ANIMAL DISEASE CONTROL CENT

Antibodies for the treatment of clostridium difficile-associated infection and disease

Provided herein are reagents, compositions, and therapies with which to treat Clostridium difficile infection and related disease conditions and pathologies, such as Clostridium difficile-associated diarrhea, resulting from infection by Clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and / or toxin B of C difficile and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.
Owner:PROGENICS PHARMA INC

Application of natural acid glycolipid molecules in neutralizing clostridium perfringens Epsilon toxin

The invention relates to an application of natural acid glycolipid molecules in neutralizing clostridium perfringens Epsilon toxin, in particular, relates to the application in preparation of relateddrugs or reagents for prevention or treatment of clostridium perfringens infection in animals, and belongs to the biomedical field. The invention discloses one or more of natural acid glycolipid molecules sialic acid, ganglioside and sulfatide, wherein the natural acid glycolipid molecules have a good neutralization effect of Epsilon toxin, and have a good therapeutic effect on either animal-lethal clostridium perfringens infection or invasion and infection of Epsilon toxin. Three kinds of natural acid molecules sialic acid, ganglioside and glucosinolate have the advantages of simple molecularstructure, economic price, easily availability on the market and the like. The natural acid glycolipid molecules are expected to be used as substitute antibiotics or antibodies for prevention and treatment of clostridium perfringens infection, and have good application prospects in animal husbandry and veterinary.
Owner:KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI +1

Cholic acid derivative with antibacterial activity and pharmaceutical composition thereof

The invention provides a compound shown as formula (I), or a stereoisomer, or a salt, or a solvate, or a prodrug, or a metabolite thereof. The compound can effectively inhibit the growth of clostridium difficile thalli, has remarkable antibacterial activity, and has a very promising application prospect in preparing medicines for preventing and / or treating clostridium difficile infectious diseases, recurrence of clostridium difficile infectious diseases or complications of clostridium difficile infectious diseases.
Owner:CHENGDU BIOBEL BIOTECHNOLOGY CO LTD

Preventive and/or therapeutic agent for clostridium difficile infection

PendingCN112823014APrevent and/or treat infectionAntibacterial agentsPharmaceutical delivery mechanismClostridium difficile infectionsGenus Enterococcus
Provided is a novel preventive and / or therapeutic agent for Clostridium difficile infection. It has been discovered that bacteria belonging to the genus Enterococcus are capable of preventing and / or curing Clostridium difficile infection. Disclosed herein are: an agent that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus; a medicinal product that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus; and a food product that is for preventing and / or curing Clostridium difficile infection and that contains a bacterium belonging to the genus Enterococcus.
Owner:NUTRI CO LTD

Compositions and methods for treating clostridium infection and preventing recurrence of infection

C. difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea. Unfortunately, antibiotic therapy remains as the standard treatment for this antibiotic-induced disease and relapses are common. Antibiotic treatment typically is given for 10 to 14 days for initial or second episode of CDI. For recurrent episodes, more prolonged courses are recommended. It is disclosed herein that lower dose or shorter course of the antimicrobial treatment is sufficient to treat the disease and prevent recurrent disease by enabling a good immunologic response to infection, and perhaps also by better preserving normal flora, thus protecting against relapses or reinfection.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Engineered flora disorder sensing probiotics for clostridium difficile infection and recurrent infection management

The present invention relates to methods of metabolic engineering of bacterial cells to produce bile salt hydrolases to inhibit germination of clostridium difficile endophytic spores and colonization within the human gastrointestinal tract. The bile salt hydrolase is operably linked to a sialic acid inducible promoter pNanA, wherein the pNanA is in turn controlled by a repressor nanoR. A recombinant bacterium expressing the bile salt hydrolase may be a probiotic strain to be used in the prevention or treatment of Clostridium difficile infection.
Owner:NAT UNIV OF SINGAPORE

Recombinant β2 protein for inhibiting Clostridium perfringens infection and its preparation method and application

The invention discloses recombinant beta-2 protein for inhibiting clostridium perfringens infection and a preparation method and application thereof. The recombinant beta-2 protein is shown in (a) or (b) or (c), wherein the protein in (a) is composed of amino acid sequences shown as SEQ ID No.2; the protein in (b) is composed of amino acid sequences shown at the sites No.51-No.286 of SEQ ID No.2; the fusion protein in (c) is obtained by fusing protein tags at carboxyl terminals or / and amino terminals of the protein shown in (a) or (b). The recombinant beta-2 protein enables animals to have a higher serum antibody level and resist the attack of clostridium perfringens after the animals are immunized with the recombinant beta-2 protein. The recombinant beta-2 protein is good in solubility and easy to purify and can serve as a diagnostic antigen to be prepared into a monoclonal antibody or be used for further research on protein functions and conformation relations.
Owner:CHINA ANIMAL DISEASE CONTROL CENT

Method for controlling clostridium infection in animals

The present invention relates to compositions and methods of inhibiting quorum sensing processes of C. perfringens using fengycin. Fengycin effectively downregulates the expression of agrD and netB genes, resulting in reduced pathogenesis of C. perfringens. The composition may contain fengycin or a source of fengycin, such as Bacillus subtilis PB6.
Owner:KEMIN IND INC
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