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Methods and compositions for reducing clostridium difficile infection

a technology of clostridium difficile and composition, which is applied in the field of methods and compositions for reducing clostridium difficile infection, can solve the problems of limited widespread adoption of fmt (pamer), and achieve the effect of reducing risk and severity

Inactive Publication Date: 2017-03-30
MEMORIAL SLOAN KETTERING CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to methods and compositions for reducing the risk and severity of C. difficile infection. The technical effect of the invention is to provide means for reducing the risk and improving resistance to C. difficile infection through the use of Clostridium scindens bacteria or an enzyme that converts primary bile acid or salt to a secondary bile acid, or a secondary bile acid. These methods and compositions may also help to decrease the severity of C. difficile infection and decrease the amount of C. difficile toxin.

Problems solved by technology

However, since the compositions of fecal transplants are complex, unstandardized, and incompletely defined, concerns about the transmission of undetected pathogens, regulatory complications, and other microbiome-influenced health outcomes (ex. obesity and inflammatory bowel disease) have limited widespread adoption of FMT (Pamer, Mucosal Immunol.

Method used

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  • Methods and compositions for reducing clostridium difficile infection
  • Methods and compositions for reducing clostridium difficile infection
  • Methods and compositions for reducing clostridium difficile infection

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Embodiment Construction

[0045]The present invention relates to methods and compositions for reducing the risk and / or severity of C. difficile infection. For clarity of description, and not by way of limitation, this section is divided into the following subsections:[0046](i) Recombinant cells;[0047](ii) Therapeutic bacteria;[0048](iii) Pharmaceutical compositions;[0049](iv) Methods of treatment; and[0050](v) Non-limiting embodiments of the disclosure.

[0051]The following are terms relevant to the present invention:

[0052]An “individual” or “subject” herein is a vertebrate, such as a human or non-human animal, for example, a mammal. Mammals include, but are not limited to, humans, primates, farm animals, sport animals, rodents and pets. Non-limiting examples of non-human animal subjects include rodents such as mice, rats, hamsters, and guinea pigs; rabbits; dogs; cats; sheep; pigs; goats; cattle; horses; and non-human primates such as apes and monkeys.

[0053]An “effective amount” of a substance as that term is...

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Abstract

The present invention relates to methods and compositions for reducing the risk and severity of C. difficile infection. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacterium Clostridium scindens, contributes substantially to resistance against C. difficile infection. Without being bound by any particular theory, it is believed that this is achieved through the biosynthesis of secondary bile acids.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application Ser. No. 62 / 000,308, filed May 19, 2014, the content of which is incorporated by reference in its entirety herein.GRANT INFORMATION[0002]This invention was made with government support under grants AI042135, AI095706 and GM007739 awarded by the National Institutes of Health. The government has certain rights in the invention.1. INTRODUCTION[0003]The present invention relates to compositions and methods for decreasing the risk of developing Clostridium difficile infection and for treating Clostridium difficile infection, should it occur.2. BACKGROUND OF THE INVENTION[0004]The gastrointestinal tract of mammals is densely colonized by hundreds of microbial species that coexist symbiotically with their hosts. The microbes, collectively referred to as the microbiota, contribute to numerous aspects of host health, including nutrient metabolism (Turnbaugh, Nature 457, 480-484 (2009...

Claims

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Application Information

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IPC IPC(8): A61K35/74C12Q1/26C12N9/04A61K38/44A61K45/06
CPCA61K35/74A61K38/443C12Q1/26A61K45/06C12N9/0006C12Y101/01159
Inventor PAMER, ERICBUFFIE, CHARLIEMCKENNEY, PETER
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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