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Chinese medicine composition for treating ulcerative colitis, Chinese medicine preparation and application thereof

A technology for ulcerative colitis and traditional Chinese medicine preparations, which can be used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Active Publication Date: 2022-03-25
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent treats ulcerative colitis through the soothing and sedative effect of the drug and prolonging the maintenance time of the drug, which only relieves the symptoms and treats the symptoms but not the root cause

Method used

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  • Chinese medicine composition for treating ulcerative colitis, Chinese medicine preparation and application thereof
  • Chinese medicine composition for treating ulcerative colitis, Chinese medicine preparation and application thereof
  • Chinese medicine composition for treating ulcerative colitis, Chinese medicine preparation and application thereof

Examples

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Effect test

Embodiment 1

[0042] The traditional Chinese medicine decoction for treating ulcerative colitis is prepared from the following components: Agrimony 15g, Burnet 10g, Woody 6g, Coptidis 9g, Atractylodes 10g, Radix Paeoniae Rubra 15g, Jiubiying 15g, Fotanmu 15g, Leech 3g .

[0043] The above-mentioned components are taken, and the traditional Chinese medicine decoction is prepared according to the existing preparation method of the traditional Chinese medicine decoction. The proportion is one dosage, and the dosage of one dosage is about 200mL.

[0044] Exemplarily, the traditional Chinese medicine decoction of the present embodiment is prepared by the following method:

[0045] Add water equivalent to 8 times the total mass of the crude drug, heat to boil, and keep boiling slightly for 2 hours to obtain the first decoction and medicinal residues after separation; for the second time, take the medicinal residues obtained after the first decoction, add Water equivalent to 6 times the total mas...

Embodiment 2

[0049] The granule for treating ulcerative colitis is prepared from the following components: Agrimony 15g, Burnet 10g, Woody Fragrance 6g, Coptidis 9g, Atractylodes 10g, Radix Paeoniae Rubra 15g, Jiubiying 15g, Fotanmu 15g, and Leech 3g.

[0050] The above components are taken, and traditional Chinese medicine granules are prepared according to the existing preparation method of traditional Chinese medicine granules.

[0051] Next, observe the therapeutic effect of the traditional Chinese medicine composition for treating ulcerative colitis of the present invention on ulcerative colitis model rats through animal experiments. In the drawings, Control represents the normal group, Model represents the model group, ZBF-2.95g / kg represents the low-dose group of traditional Chinese medicine, ZBF-5.88g / kg represents the medium-dose group of Chinese medicine, ZBF-11.76g / kg represents the high-dose group of Chinese medicine Dosage group, Mesalazine represents the mesalazine group.

...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating ulcerative colitis, which is prepared from the following raw material components in parts by mass: Agrimony 10-30g, Burnet 9-15g, Woody Fragrance 6-10g, Coptidis 3-10g, Atractylodes 6-15g, Radix Paeoniae Rubra 6-15g, Jiubiying 9-30g, Fotanmu 9-30g, Leech 1-5g. The efficacy of the Chinese medicinal prescription of the present invention is verified by the UC animal model, and the results suggest that the Chinese medicinal prescription of the present invention can significantly reduce the intestinal mucosal ulcer, inflammation and edema of the UC model rats, and can reduce the intestinal tissue inflammation of the model rats. Cell infiltration, reducing crypt damage, and its effect is equivalent to the positive drug mesalamine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating ulcerative colitis and its preparation and application. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific intestinal inflammation with unknown etiology, multi-factors, and multi-layers. one. [0003] The pathological factors of UC mainly include: damp evil (heat), blood stasis, heat toxin, phlegm turbidity, qi stagnation, blood stasis, etc.; pathological characteristics: the active stage is mostly syndrome, and the main pathogenesis is damp-heat accumulation in the intestines, and disorder of qi and blood , and severe heat-toxin and stasis-heat are the main factors, and those who are refractory to recovery should consider the factors of phlegm turbidity and blood stasis; the remission period is mostly mixed with deficiency and excess, and the main pathogenesis is spleen ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/739A61P1/04A61K35/62
CPCA61K36/73A61K36/739A61K36/285A61K36/718A61K36/284A61K36/71A61K36/65A61K36/185A61K36/704A61K35/62A61P1/04A61K2300/00
Inventor 黄绍刚秦书敏郑欢吴皓萌黄马养潘琪谋陈君千占凯饶珂寒
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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